Room Temperature Organic Synthesis

 
 
Elsevier (Verlag)
  • 1. Auflage
  • |
  • erschienen am 19. März 2015
  • |
  • 386 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-801138-6 (ISBN)
 

Filling a gap in the scientific literature, Room Temperature Organic Synthesis is unique in its authoritative, thorough, and applied coverage of a wide variety of 'green' organic synthetic methodologies. The book describes practical, feasible protocols for room temperature reactions to produce carbon-carbon and carbon-heteroatom bond formations including aliphatic, aromatic, alicyclic, heterocycles, and more. Consistently organized for easy access, each selected reaction is discussed in a very compact and structured manner including: reaction type, reaction condition, reaction strategy, catalyst, keywords, general reaction scheme, mechanism (in selected cases), representative entries, experimental procedure, characterization data of representative entries, and references. This book will be a valuable resource for synthetic organic, natural products, medicinal, and biochemists as well as those working in the pharmaceutical and agrochemical industry.


  • Includes more than 300 protocols for a green approach to organic synthesis
  • Provides specific detail about experimental conditions
  • Increases efficiency in the laboratory by eliminating time-consuming literature searches


Professor Dr. Goutam Brahmachari was born at Barala in the district of Murshidabad (West Bengal), India, on April 14, 1969. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher secondary Education (WBCHSE). Then he moved to Visva-Bharati (a central university founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, Prof. Brahmachari completed his masters in 1992 with specialization in organic chemistry and thereafter received his PhD degree in 1997 in chemistry from the same university. He was appointed as assistant professor of organic chemistry in the Department of Chemistry, Visva-Bharati University, in 1998, and became associate professor in 2008. In 2011, he became full professor of organic chemistry in the same faculty. At present, he is responsible for teaching courses in organic chemistry, natural products chemistry, and physical methods in organic chemistry. Several students have received their PhD degree under the supervision of Prof. Brahmachari during this period, and a couple of research fellows are presently working with him both in the fields of natural products and synthetic organic chemistry. He serves as a member of the Indian Association for the Cultivation of Science (IACS) and Indian Science Congress Association (ISCA), Kolkata, and as an Editor-in-Chief, Signpost Open Access Journal of Organic and Biomolecular Chemistry. He also serves as an editorial advisory board member for several journals and is the Who's Who in the World-2015 Listee. He is a recipient of the 3rd Academic Brilliance Award-2015 (Award for Excellence in Research).
Prof. Brahmachari's research interests include (i) synthetic organic chemistry with special emphasis on green chemistry; (ii) isolation, structural determination, and/or detailed NMR study of new natural products from medicinal plants; (iii) semi-synthetic studies with natural products; and (iv) evaluation of biological activities and pharmacological potential of natural and synthetic compounds. With more than 16 years of teaching experience, he has produced so far nearly 120 scientific publications including original research papers, review articles, and invited book chapters in edited books in the field of natural products and organic synthesis from internationally reputed presses. Prof. Brahmachari has authored/edited a number of text and major reference books that include Organic Name Reactions: A Unified Approach (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2006), Chemistry of Natural Products: Recent Trends & Developments (Research Signpost, 2006), Organic Chemistry Through Solved Problems (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2007), Natural Products: Chemistry, Biochemistry and Pharmacology (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2009), Handbook of Pharmaceutical Natural Products-2 volume-set (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2010), Bioactive Natural Products: Opportunities & Challenges in Medicinal Chemistry (World Scientific Publishing Co. Pte. Ltd., Singapore, 2011), Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds (CRC Press, Taylor & Francis group, USA, 2013), Natural Bioactive Molecules: Impacts & Prospects (Narosa Publishing House, New Delhi; co-published by Alpha Science International, Oxford, 2014), Green Synthetic Approaches for Biologically Relevant Heterocycles (Elsevier Inc., USA, 2014), and Bioactive Natural Products-Chemistry & Biology (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2015).
He is regularly consulted as a referee by leading international journals including Elsevier, Royal Society of Chemistry, American Chemical Society, Wiley, Taylor & Francis, Springer, Bentham Science, Indian Chemical Society, Pakistan Chemical Society, Korean Chemical Society, Brazilian Chemical Society, Bulgarian Academy of Sciences, and so on, and also various financial commissions.
Prof. Brahmachari enjoys Songs of Rabindranath Tagore and finds interests in Literature as well!
  • Englisch
  • Saint Louis
  • |
  • USA
Elsevier Science
  • 29,09 MB
978-0-12-801138-6 (9780128011386)
0128011386 (0128011386)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Room Temperature Organic Synthesis
  • Copyright
  • Dedication
  • Contents
  • Foreword
  • How to Read
  • Preface
  • Chapter 1: Carbon - Carbon Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of the representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • Further information
  • Reaction scheme
  • Experimental procedure
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedures
  • Characterization data of representative entries
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • Further information
  • References
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Reaction scheme
  • Experimental procedure
  • Characterization data of one representative entry
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative entry
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Chapter 2: Carbon - Nitrogen Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Representative new entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Further information
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • References for spectroscopic data
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative new entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative new entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • Further information
  • General reaction scheme
  • Representative new entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Further information
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Further information
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • References for spectroscopic data
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Reference
  • Further Information
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction schemes
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Further information
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Further information
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • Further information
  • Chapter 3: Carbon - Oxygen Bond Forming Reactions at Room Temperature
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data for two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data for one representative compound
  • Reference
  • Reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • Reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Extension
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data for one representative compound
  • Reference
  • General reaction scheme
  • Proposed Mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data for two representative compounds
  • Reference
  • General reaction scheme
  • Proposed Mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data for two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data for two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data for one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedures
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • Chapter 4: Carbon - Sulfur Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characteristic data for two compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characteristic data for the four types of compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characteristic data for two compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characteristic data for two compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Proposed Mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Chapter 5: Carbon - Phosphorus Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Plausible mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme:
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Further information
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • Chapter 6: Carbon - Halogen Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of representative compounds
  • Reference
  • Chapter 7: Carbon - Boron Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction schemes
  • Grignard conditions
  • Barbier conditions
  • Representative entries
  • Experimental procedure
  • Under Grignard conditions
  • Under Barbier conditions
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of one representative compound
  • Reference
  • Chapter 8: Miscellaneous Bond Forming Reactions at Room Temperature
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative entries
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Characterization data of two representative compounds
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction schemes
  • Representative entries
  • Experimental procedures
  • Characterization data of one representative sulfonamide compound
  • Reference
  • General reaction scheme
  • Mechansim-1
  • Mechansim-2
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedure
  • Reference
  • General reaction scheme
  • Proposed mechanism
  • Representative entries
  • Experimental procedures
  • Reference
  • General reaction scheme
  • Representative entries
  • Experimental procedures
  • Characterization data of two representative compounds
  • Reference
  • Index
  • Abstract and keywords
Chapter 1

Carbon - Carbon Bond Forming Reactions at Room Temperature


C-C bond_1

Type of reaction: C-C bond formation

Reaction conditions: Solvent-free, room temperature

Synthetic strategy: One-step condensation

Catalyst: Niobium pentachloride (NbCl5)

Keywords: 1,4-Dicarbonyls, aldehydes, niobium pentachloride (NbCl5), homogeneous catalysis, solvent-free, room temperature, condensation, Knoevenagel reaction, trisubstituted alkenes

General reaction scheme


Representative entries






Experimental procedure


A round-bottomed flask was charged with a magnetic stir bar, 1,3-carbonyl compound (1; 1 mmol), and aldehyde (2; 1.2 mmol), followed by 20 mol% of NbCl5. The reaction mixture was then stirred at room temperature for required time-frame (0.75-4.0 h). After completion of the reaction, it was quenched by the addition of saturated aqueous NaHCO3 solution and the product (3) was extracted with ethyl acetate. The product was purified by column chromatography using ethyl acetate/hexane as eluent. Structure of each of the products was verified from IR, 1H NMR, 13C NMR and HRMS studies.

Characterization data of two representative compounds


(E)-Methyl 2-(4-chlorobenzylidene)-3-oxobutanoate (3a): Reddish solid; mp 80 °C; IR (KBr): 821, 1088, 1250, 1618, 1654, 1733, 2362, 2855, 2932 cm- 1; 1H NMR (300 MHz, CDCl3): d 1.16 (s, 3H), 2.58 (s, 3H), 6.11-6.12 (m, 4H), 6.27 (s, 1H); 13C NMR (75 MHz, CDCl3): d 26.5, 52.6, 129.1, 130.6, 136.8, 134.5, 140.0, 169.7, 194.3; ESIMS: m/z 261 (M+ + Na); HRMS: Calcd for C12H11O3NaCl, 261.0294; Found 261.0289.

3-(4-Methoxybenzylidene)pentane-2,4-dione (3c): Yellow liquid; IR (neat): 831, 1108, 1174, 1258, 1258, 1513, 1599, 1653, 1706, 2844, 2926, 3004 cm- 1; 1H NMR (300 MHz, CDCl3): d 2.28 (s, 3H), 2.26 (s, 3H), 3.83 (s, 3H), 6.87 (d, J = 9.0 Hz, 2H), 7.31 (d, J = 9.0 Hz, 2H), 7.37 (s, 1H); 13C NMR (75 MHz, CDCl3): d 26.2, 31.6, 55.3, 114.5, 125.2, 131.6, 139.7, 140.6, 161.6, 196.4, 206.1; ESIMS: m/z 241 (M+ + Na); HRMS: Calcd for C13H14O3Na, 241.0840; Found 241.0833.

Reference


Yadav JS, Bhunia DC, Singh VK, Srihari P. Solvent-free NbCl5 catalyzed condensation of 1,3-dicarbonyl compounds and aldehydes: A facile synthesis of trisubstituted alkenes. Tetrahedron Lett. 2009;50:2470-2473.

C-C bond_2

Type of reaction: C-C bond formation

Reaction conditions: Water, neutral conditions, room temperature

Synthetic strategy: One-step condensation

[Cage 1: adapted from Murase et al. (2012), J. Am. Chem. Soc., 134, 162]

Catalyst: Heterogeneous, a cationic coordination cage (1) (12 + charged M6L4 cage) [Cage components: (ethylene diamine)Pd(NO3)2 and 2,4,6-tripyridyl-1,3,5-triazine]

Keywords: Aromatic aldehydes, Meldrum's acid, 12 + charged cage 1 (catalyst), water, room temperature, condensation, Knoevenagel reaction, trisubstituted alkenes

General reaction scheme


Representative entries






Experimental procedure


Aldehyde (2; 0.5 mmol) and Meldrum's acid (3; 0.5 mmol) were added to an aqueous solution (5 mL) of cage (1; 15.0 mg, 5.00 × 10-3 mmol; 1 mol%), and the reaction mixture was stirred at room temperature for stipulated time (6-96 h). The product was extracted with CHCl3 (2 × 5 mL), and the organic layer was evaporated in vacuo to furnish the condensation product 4 (38-96% yield). The obtained product 4 was purified by recrystallization from refluxing ethanol. Each of the products was fully characterized from its detailed spectral studies including IR, 1H NMR, 13C NMR, MS, and also from analytical analyses.

Cage 1 - a synthetic mimic of enzymes: This technique demonstrated a unique dehydration condensation under neutral conditions in water catalyzed by the water-soluble synthetic cationic host 1. An aromatic aldehyde substrate (2; an electron-rich guest) first became efficiently encapsulated into the host's (1) hydrophobic cavity, which after then attacked by the enolate of Meldrum's acid (3) to generate oxyanion intermediate. The condensation reaction seems to be facilitated by the anionic intermediate in the cationic environment of the cage. The eventual loss of water molecule occurs smoothly within the hydrophobic cavity to form the dehydrated product (4) which is too large for the cavity and is spontaneously released from the cage, and a new incoming substrate molecule (2) occupies the position. The overall phenomenon follows the tricks of enzyme-like catalysis.

Characterization data of two representative compounds


5-((6-Methoxynaphthalen-2-yl)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (4c): Solid, mp 191.2-192.2 °C; IR (ATR): 2992, 2946, 1756, 1725, 1587, 1402, 1341, 1291, 1222, 1158, 1023, 1010 cm-1; 1H NMR (500 MHz, CDCl3): d 8.56 (br s,1H), 8.55 (br s,1H), 8.18 (dd, J = 8.8, 1.7 Hz, 1H), 7.85 (d, J = 9.0 Hz, 1H), 7.76 (d, J = 8.8 Hz, 1H), 7.21 (dd, J = 9.0, 2.4 Hz, 1H,), 7.16 (d, J = 2.4 Hz, 1H), 3.97 (s, 3H), 1.83 (s, 6H); 13C NMR (125 MHz, CDCl3): d 163.8 (C), 160.9 (C), 160.3 (C), 158.5 (CH), 137.8 (C), 137.7 (CH), 131.7 (CH), 129.4 (CH), 128.1 (C), 127.3 (C), 127.1 (CH), 120.0 (CH), 112.7 (C), 106.0 (CH), 104.4 (C), 55.6 (CH3), 27.6 (CH3); GC-MS (EI): m/z = 312 [M]+. Anal. Calcd. for C18H16O5: C, 69.22; H, 5.16. Found: C, 69.11; H, 5.32.

5-(Anthracen-9-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (4d): Solid, mp 193.6-194.3 °C; IR (ATR): 3049, 3031, 3013, 2925, 2854, 1764, 1737, 1631, 1446, 1396, 1385, 1365, 1334, 1292, 1218, 1202, 1123, 1067, 1028; 1H NMR (500 MHz, CDCl3): d 9.47 (s, 1H), 8.55 (s, 1H), 8.06 (d, J = 8.8 Hz, 2H), 7.84 (d, J = 9.1 Hz, 2H), 7.52 (t, J = 9.1 Hz, 1H), 7.50 (t, J = 8.8 Hz, 1H), 1.90 (s, 6H); 13C NMR (125 MHz, CDCl3): d 161.91 (C), 157.89 (C), 157.75 (CH), 130.94 (C), 130.29 (CH), 129.34 (CH), 128.63 (C), 127.09 (CH), 126.80 (C), 125.58 (CH), 124.52 (CH), 121.02 (C), 104.97 (C), 28.17 (CH3); GC-MS (EI): m/z = 332 [M]+. Anal. Calcd. for C21H16O4: C, 75.89; H, 4.85; Found: C, 75.66; H, 5.03.

Reference


Murase T, Nishijima Y, Fujita M. Cage-catalyzed knoevenagel condensation under neutral conditions in water. J. Am. Chem. Soc. 2012;134:162-164.

C-C bond_3

Type of reaction: C-C bond formation

Reaction conditions: Ethanol / dichloromethane, room temperature

Synthetic strategy: E or Z-Selective Knoevenagel condensation

Catalyst: Piperidine

Keywords: Aldehydes, O-acetoacetylTEMPO (2,2,6,6-tetramethylpiperidin-1-yl 3-oxobutanoate), N-methoxy-N-methyl-3-oxobutanamide, piperidine, ethanol, room temperature, E- and Z-selective Knoevenagel condensation, trisubstituted E or Z-2-alkenes

General reaction scheme


Representative entries




Experimental procedure


A typical procedure for Knoevenagel condensaton of O-acetoacetylTEMPO (1). To a cooled (0-4 °C) mixture of O-acetoacetylTEMPO (1; 243 mg, 1.0 mmol), 2-furaldehyde (2; 192 mg, 2.0 mmol), and ethanol (4 drops, 20 mg) was added piperidine (two drops, 10 mg). The mixture was allowed to warm gradually to room temperature and was stirred for 2 days. The reaction was quenched with cold aqueous ammonium chloride, and the products were extracted with ethyl acetate. The extracts were washed with brine, dried (MgSO4), and...

Dateiformat: EPUB
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat EPUB ist sehr gut für Romane und Sachbücher geeignet - also für "fließenden" Text ohne komplexes Layout. Bei E-Readern oder Smartphones passt sich der Zeilen- und Seitenumbruch automatisch den kleinen Displays an. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Dateiformat: PDF
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat PDF zeigt auf jeder Hardware eine Buchseite stets identisch an. Daher ist eine PDF auch für ein komplexes Layout geeignet, wie es bei Lehr- und Fachbüchern verwendet wird (Bilder, Tabellen, Spalten, Fußnoten). Bei kleinen Displays von E-Readern oder Smartphones sind PDF leider eher nervig, weil zu viel Scrollen notwendig ist. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Download (sofort verfügbar)

128,52 €
inkl. 19% MwSt.
Download / Einzel-Lizenz
ePUB mit Adobe DRM
siehe Systemvoraussetzungen
PDF mit Adobe DRM
siehe Systemvoraussetzungen
Hinweis: Die Auswahl des von Ihnen gewünschten Dateiformats und des Kopierschutzes erfolgt erst im System des E-Book Anbieters
E-Book bestellen

Unsere Web-Seiten verwenden Cookies. Mit der Nutzung dieser Web-Seiten erklären Sie sich damit einverstanden. Mehr Informationen finden Sie in unserem Datenschutzhinweis. Ok