Assisted Reproductive Technologies and Infectious Diseases

A Guide to Management
Springer (Verlag)
  • erschienen am 11. Juli 2016
  • |
  • XIII, 207 Seiten
E-Book | PDF mit Wasserzeichen-DRM | Systemvoraussetzungen
978-3-319-30112-9 (ISBN)

This concise and practical book is the first of its kind to examine the use of assisted reproductive technologies (ART) in relation to blood-borne infectious diseases: human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV). The book opens with a discussion of the impact of these viruses on male and female fertility, followed by specific chapters of each of them, including ART with HIV and HCV serodiscordant couples (where either the male or female is positive) and the detection and impact of HBV and HCV in human gametes and embryos. An important character on laboratory safety when performing ART with blood-borne viruses follows, and the book concludes with a discussion of ART in austere and resource-poor settings, where these infections are often dominant due to lack of treatment and access to vaccines. Written and edited by an international array of experts in reproductive medicine, Assisted Reproductive Technologies and Infectious Diseases explores questions, techniques, and related issues with the aim of effectively helping clinicians working with serodiscordant couples wishing to have children.

1st ed. 2016
  • Englisch
  • Cham
  • |
  • Schweiz
Springer International Publishing
  • 6
  • |
  • 5 farbige Tabellen, 1 s/w Abbildung, 6 farbige Abbildungen, 6 s/w Tabellen
  • |
  • 1 schwarz-weiße und 6 farbige Abbildungen, 6 schwarz-weiße und 5 farbige Tabellen, Bibliographie
  • 7,14 MB
978-3-319-30112-9 (9783319301129)
weitere Ausgaben werden ermittelt

Andrea Borini, MD

Scientific Director, Center for Fertility and Family Health

Bologna, Italy

Valeria Savasi, MD, PhD

Chief of Reproductive Unit

Unit of Obstetrics and Gynecology

Department of Biomedical and Clinical Sciences

Hospital "L. Sacco"

University of Milan

Milan, Italy

  • Intro
  • Preface
  • Contents
  • Contributors
  • Chapter 1: The Impact of Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) on Male and Female Fertility
  • Introduction
  • HIV and Semen Parameters
  • HIV in the Genital Tract
  • cART and Semen Parameters
  • Conception in HIV-Infected Men
  • HIV and Female Fertility
  • Conception in HIV-Infected Women
  • Hepatitis B Characteristics
  • HBV and the Male Genital Tract
  • HBV and Male Fertility
  • HBV and Female Fertility
  • HCV Transmission
  • HCV and Male Fertility
  • Therapy for HCV and Male Fertility
  • HCV and Female Fertility
  • Conclusion
  • References
  • Chapter 2: HBV Virus in the Future
  • Introduction
  • HBV Mutants
  • Basal Core Promoter, Pre-C/C Gene Mutants
  • X Gene Mutations
  • Polymerase Gene Mutants
  • PreS/S Gene Mutants
  • HBV Genotypes
  • The Origin of HBV
  • The Origin and Evolution of Genotype D
  • The Origin and Evolution of Genotype A
  • The Origin and Evolution of Genotype E
  • The Origin and Evolution of Genotypes F and H
  • Origin and Evolution of HBV Genotypes B and C
  • Other Geno-/Subgenotypes of Interest
  • Clinical Implications of HBV Variability
  • HBeAg Expression and Viral Genotypes
  • Progression of the Infection
  • HBV Genotype and CH Therapy
  • Modes of Transmission
  • References
  • Chapter 3: Reproductive Assistance in HIV-Serodiscordant Couples Where the Man Is Positive
  • Introduction
  • The Presence of HIV in the Ejaculate of Seropositive Males
  • Factors Conditioning HIV Transmission Mediated by Sperm
  • Assisted Reproductive Technology in HIV-­Positive Males
  • Semen Quality in Seropositive Men
  • Sperm-Washing to Eliminate HIV from Semen
  • Sperm-Washing Protocol
  • HIV Detection in Either Semen or Washed Sperm
  • Prediction of the Result of Seminal Washing
  • Effectiveness of Washed Sperm in ART
  • Use of Artificial Insemination vs Intracytoplasmic Injection
  • Ethical and Social Issues
  • Conclusions
  • References
  • Chapter 4: Reproductive Assistance in HIV-Serodiscordant Couples Where the Woman Is Positive
  • Introduction
  • The Virus
  • Epidemiology of HIV/AIDS
  • Women and HIV
  • Fertility in HIV-Infected Women
  • Therapeutic Management
  • ARTs in HIV-Infected Women
  • ART Selection in the HIV-Infected Woman
  • Self-Insemination
  • Clinical Study of the Couple
  • Artificial Insemination or In Vitro Fertilisation
  • Ovarian Stimulation
  • Ovum Pick-Up
  • Embryo Transfer
  • ART Outcomes in Couples with an HIV-­Infected Female
  • Possible Causes of a Decline in Fertility
  • Mitochondrial Origin
  • Viral Origin
  • Endocrinological Origin
  • Immune Origin
  • Pregnancy in the HIV-Infected Woman
  • Factors Affecting the Risk of Mother-to-Child Transmission
  • Interventions for the Prevention of Mother-­to-­Child Transmission
  • Identification of the Infected Women
  • Use of Antiretroviral Drugs
  • Complications Using Antiretroviral Therapy
  • Obstetric Procedures
  • Pregnancy Outcomes in HIV-Positive Women
  • Conclusions
  • References
  • Chapter 5: The Presence of Hepatitis B and C Virus in Human Gametes and Embryos
  • The Presence of HBV in Human Gametes and Embryos
  • HBV Infection in Semen
  • HBV Infection in Oocytes
  • In Vitro Fertilisation/Intracytoplasmic Sperm Injection Outcomes with HBV-Infected Couples
  • HCV in Oocytes and Embryos
  • The Effect of HCV Infection
  • The Mechanism for HCV Mother-to-Child Transmission
  • HCV Infection and Assisted Reproduction Technologies
  • HCV in Gametes and Embryos
  • Conclusion
  • References
  • Chapter 6: Detection of Hepatitis C Virus in the Semen of Infected Men and Reproductive Assistance in HCV Discordant Couples: An Overview
  • Epidemiology of Hepatitis C Virus Infection
  • Transmission of Hepatitis C Virus
  • Detection of Hepatitis C Virus in the Semen of Infected Men and Reproductive Assistance in HCV-Discordant Couples
  • Conclusion
  • References
  • Chapter 7: Laboratory Safety During Assisted Reproduction in Patients with a Bloodborne Virus
  • Risk of Cross-Contamination and Nosocomial Transmission
  • BBV Infection Risk Related to Cryopreservation
  • Safety Measurements
  • Concern About Natural Conception in HIV-Serodiscordant Couples
  • Attitude Regarding Gamete Donors
  • BBV Infection Risk and Attitude Regarding Health Care Workers
  • Legitimacy of BBV Screening Before Infertility Treatment
  • Conclusion
  • References
  • Chapter 8: Accessibility to Reproductive Assistance in Low-Income Countries
  • Introduction
  • Prevalence of Infertility in Low-Income Countries
  • Aetiology and Risk Factors for Infertility in Low-Income Countries
  • Reproductive Tract Infections
  • Unsafe Abortion and Healthcare Practices
  • Sociocultural Factors
  • Nutritional and Environmental Factors
  • Psychosocial, Religious and Political Aspects of Infertility
  • Prevention of Infertility
  • Provision of Reproductive Assistance
  • Affordable Infertility Care
  • Assisted Reproductive Technologies and HIV in Low-Income Countries
  • Conclusion
  • References
  • Index

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