Custom-designed for clinicians on the frontline of treatment and prevention of the human papillomavirus (HPV), this stand-alone handbook provides the scientific background needed to understand and administer the new HPV vaccines. Written by some of the discoverers of these vaccines, this accessible text explores the biology and epidemiology of HPV,
WILLIAM BONNEZ is Associate Professor of Medicine, University of Rochester; Attending Physician, Strong Memorial Hospital; and Attending Physician, Highland Hospital, Rochester, New York, USA. Dr. Bonnez received his M.D. from the Universite de Bordeaux II (now called Universite Victor Segalen Bordeaux II), Bordeaux, France. As one of the discoverers of the groundbreaking HPV vaccines, his contributions to the field of infectious disease are truly immeasurable. Dr. Bonnez is a member and fellow of several professional societies, including the American College of Physicians, the Infectious Disease Society of America, and the American Society for Virology. In addition, he has received several notable awards throughout his career, such as the Annual Davey Memorial Award for Outstanding Contribution to Cancer Research and the Wilmot's Inspiration Award (both from the University of Rochester), Distinguished Inventor of the Year 2006 from the Rochester Intellectual Property Law Association, and the Health Care Achievement Award from the Rochester Business Journal. Dr. Bonnez has been an honored guest lecturer and presenter at various international, national, and regional meetings and symposiums on infectious and sexually transmitted diseases, and he frequently contributes to numerous journal publications by serving on editorial and review boards. Such publications include The Open Virology Journal, Antiviral Therapy, and The Journal of Infectious Diseases.
Preface. Overview. 1: Biology. Basic Virology. Structure. Classification and Disease Association. Genome Organization. Viral Proteins. Growth in Cell Cultures and Animal Models. Antigenicity. Pathogenesis. Molecular and Cellular Pathogenesis. Active Infection. Oncogenesis. Latency. Immunology. Humoral Response. Cellular Innate and Adaptative Response. References. 2: Epidemiology. Incidence and Prevalence. Risk Factors. HPV and Cancer, the Casual Link. Transmission and Reinfection. Natural History. References. 3: HPV Diseases. External Anogenital Warts. Other Diseases of the Anogenital Tract. Diseases of the Head and Neck Area. References. 4. Treatment. The Armamentarium. Chemical Methods. Physical Methods. Approach to Treatment. External Anogenital Warts. Other Diseases of the Anogenital Tract. Diseases of the Head and Neck Area. References. 5: Diagnosis. Cytology and Colposcopy. Histology. Nucleic Acid Detection Methods. Serology. References. 6: Screening. Screening Strategies. Appropriate Use of HPV DNA Testing. New Screnning Markers. References. 7: Prevention. Condoms and Microbicides. Vaccination. Vaccine Preclinical and Early Clinical Development. Gardasil/Silgard. Clinical Trials. Phase I Studies. Phase II Studies. Phase III and IV Studies. The Vaccine. Vaccine Recommendations. Availability. Duration of Immunity. Contraindications. Adverse Events. Cervarix. Clinical Trials. Phase I Studies. Phase II Studies. Phase III and IV Studies. The Vaccine. Vaccine Recommendations. Availability. Duration of Immunity. Contraindications. Adverse Events. Other Vaccines in Development. Benefits, Obstacles, and Strategies to Implement HPV Vaccination. Unanswered Questions. References.