Chromatin Signaling and Diseases

 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 6. August 2016
  • |
  • 466 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-802609-0 (ISBN)
 

Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling.

After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling.

Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored.


  • Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging
  • Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology
  • Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling
  • Helps researchers learn about the quickly expanding field of chromatin signaling
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 10,69 MB
978-0-12-802609-0 (9780128026090)
012802609X (012802609X)
weitere Ausgaben werden ermittelt
  • Front Cover
  • CHROMATIN SIGNALING AND DISEASES
  • Translational Epigenetics Series
  • CHROMATIN SIGNALING AND DISEASES
  • Copyright
  • Contents
  • List of Contributors
  • Bases of Chromatin Signaling and Their Impact on Diseases Pathogenesis
  • CHROMATIN STRUCTURE AND DYNAMICS
  • GENE EXPRESSION
  • CHROMATIN SIGNALING
  • ROLE OF CHROMATIN SIGNALING IN HUMAN PATHOLOGIES
  • BOOK OPENING REMARKS
  • References
  • I - HISTONE MARK WRITERS
  • 1 - Histone Acetyltransferases, Key Writers of the Epigenetic Language
  • INTRODUCTION
  • FUNCTIONAL AND MECHANISTIC IMPACT OF HISTONE ACETYLATION
  • IDENTIFICATION OF THE FIRST HISTONE ACETYLTRANSFERASES, A HISTORICAL PERSPECTIVE
  • Identification of a Histone Deposition-Related Histone Acetyltransferase
  • Identification of Transcription-Related Histone Acetyltransferases
  • YEAST HISTONE ACETYLTRANSFERASES BELONG TO THREE DIFFERENT FAMILIES
  • The GNAT Family of Histone Acetyltransferases
  • The MYST Family of Histone Acetyltransferases
  • Rtt109 as a Unique Fungal-Specific Histone Acetyltransferase
  • General Principles About Yeast Histone Acetyltransferases
  • THREE FAMILIES OF METAZOAN HISTONE ACETYLTRANSFERASES AND THEIR ROLES IN ANIMAL DEVELOPMENT
  • The GNAT Family of Histone Acetyltransferases and Their Roles in Animal Development
  • p300, CBP, and Their Functions in Different Developmental Processes
  • MYST Proteins, Multisubunit Complexes, and Functions in Animal Development
  • ROLE OF HISTONE ACETYLTRANSFERASES IN THE PATHOGENESIS OF HUMAN DISEASES
  • GNATs in Cancer, Neurodegenerative Disorders, and Genetic Diseases
  • p300 and CBP in Rubinstein-Taybi Syndrome and Different Types of Cancer
  • MYST Proteins in Cancer and Developmental Disorders
  • CONCLUSIONS AND FUTURE DIRECTIONS
  • List of Acronyms and Abbreviations
  • Glossary
  • References
  • 2 - Impacts of Histone Lysine Methylation on Chromatin
  • CHROMATIN REGULATION AND POSTTRANSLATIONAL MODIFICATIONS
  • Modification of Lysine Residues on Histones
  • Lysine Methylation of Histones
  • Identification of Histone Lysine Methylation
  • HISTONE LYSINE METHYLTRANSFERASES
  • SET Domain Lysine Methyltransferases
  • Seven ß-strand Lysine Methyltransferases
  • HISTONE H3K4 METHYLATION (FIG. 2.1)
  • Distribution and Recognition of H3K4 Methylation
  • Deconstructing a COMPASS
  • Regulation of KMT2 Enzymatic Activity by the WRAD Complex
  • KMT2 Enzymes and Leukemia
  • HISTONE H3K9 METHYLATION (FIG. 2.1)
  • H3K9 Methyltransferases
  • Distribution of Methylated H3K9
  • Establishment of Pericentromeric Heterochromatin and H3K9 Methylation
  • Transcriptional Regulation by G9a/GLP
  • Interplay Between H3K9 and DNA Methylation
  • Links Between Histone H3K9 Methylation and Diseases
  • HISTONE H3K27 METHYLATION (FIG. 2.1)
  • Histone H3K27 Methyltransferases
  • Distribution of Methylated H3K27 Across the Chromatin Landscape
  • EZH2 and the PRC2 Complex
  • EZH2 in Gene Silencing
  • EZH2 in Chromosome Xi Silencing
  • H3K27me Alterations in Cancers
  • HISTONE H3K36 METHYLATION
  • Genomic Landscape of H3K36 Methylation
  • H3K36 methyltransferases (Fig. 2.1)
  • The Role of H3K36 Methylation During Transcription and DNA Damage
  • Mechanistic Insights Into H3K36 Methylation
  • Methylation of H3K36 and NSD Methyltransferases in Sotos and Wolf-Hirschhorn Syndromes and Cancers
  • HISTONE H3K79 METHYLATION (FIG. 2.1)
  • Distribution of Mono-, Di-, and Trimethylated H3K79 Across the Chromatin Landscape
  • Crosstalk Between H3K79 Methylation and the Silent Information Regulator Complex
  • Histone H2B Ubiquitination Links Dot1 Activity to Transcription
  • Dot1 KMT Activities During the DNA Damage Response
  • The Role of Dot1 Methyltransferase in Acute Myeloid Leukemias
  • Mechanistic Determinants Controlling H3K79 Recognition by Dot1
  • HISTONE H4K20 METHYLATION
  • H4K20 Methyltransferases (Fig. 2.1)
  • Distribution of H4K20me
  • MONOMETHYLATION OF H4K20 PROMOTES MITOTIC CHROMATIN CONDENSATION AND DNA REPLICATION
  • Importance of SET8 Catalytic Activity in the DNA Damage Response
  • Transcriptional Repression by H4K20 Monomethylation
  • Di- and Trimethylation of H4K20 by SUV420H1/H2
  • H4K20 Methylation and Diseases
  • EMERGING ROLES OF NON-CANONICAL HISTONE LYSINE METHYLATION
  • CONCLUSIONS
  • List of Acronyms and Abbreviations
  • References
  • 3 - The Role of Histone Mark Writers in Chromatin Signaling: Protein Arginine Methyltransferases
  • INTRODUCTION
  • GENERAL PROPERTIES OF PROTEIN ARGININE METHYLTRANSFERASES
  • Characteristics of an Arginine Residue
  • Classification of Protein Arginine Methyltransferases
  • Properties of Protein Arginine Methyltransferases
  • Readers of Arginine Methylation
  • Regulation of Protein Arginine Methyltransferases
  • MAMMALIAN PROTEIN ARGININE METHYLTRANSFERASES AND THEIR EFFECTS ON GENE EXPRESSION
  • Protein Arginine Methyltransferase 1
  • Protein Arginine Methyltransferase 2
  • Protein Arginine Methyltransferases 4/Co-activator-associated Arginine Methyltransferase 1
  • Protein Arginine Methyltransferase 5
  • Protein Arginine Methyltransferase 6
  • Protein Arginine Methyltransferase 7
  • CONCLUSIONS
  • List of Acronyms and Abbreviations
  • Glossary
  • Acknowledgments
  • References
  • 4 - Histone Kinases and Phosphatases
  • INTRODUCTION
  • HISTONE PHOSPHORYLATION: BASIC CONCEPTS
  • HISTONE KINASES IN NUCLEOSOME PACKING AND ASSEMBLY
  • HISTONE KINASES AND CELL DIVISION
  • Displacement
  • Chromosome Condensation
  • Landmarks
  • Building the Kinetochore
  • HISTONE KINASES IN DNA REPAIR AND REPLICATION
  • HISTONE KINASES AND PROGRAMMED CELL DEATH
  • HISTONE KINASES AND TRANSCRIPTION
  • H3S10 and H3S28 Kinases
  • How Do H3S10ph and H3S28ph Regulate Transcription?
  • Phosphorylation of Other H3 Residues
  • Phosphorylation of H2B and H4
  • HISTONE PHOSPHATASES
  • CONCLUSIONS
  • List of Acronyms and Abbreviations
  • Glossary
  • References
  • II - HISTONE MARK READERS
  • 5 - The Bromodomain as an Acetyl-Lysine Reader Domain
  • LYSINE ACETYLATION AND THE BROMODOMAIN
  • DISCOVERY OF THE BROMODOMAIN AS AN ACETYL-LYSINE RECOGNITION MODULE
  • BIOLOGICAL FUNCTIONS OF BROMODOMAIN PROTEINS
  • Interaction With Other Chromatin-Associated Modules
  • Bromodomain Proteins and Lysine-Mediated Interactions in Gene Transcription
  • BROMODOMAIN PROTEINS IN HUMAN DISEASE PATHWAYS
  • SMALL MOLECULAR INHIBITORS OF BROMODOMAINS
  • CONCLUSION
  • List of Acronyms and Abbreviations
  • Acknowledgments
  • References
  • 6 - Chromo Domain Proteins
  • INTRODUCTION
  • THE CHROMO DOMAIN STRUCTURE
  • VARIETIES OF CHROMO DOMAINS
  • HP1 Family Proteins
  • Polycomb Family Proteins
  • Chromo Domain Y Chromosome Family
  • Chromo Methyltransferases
  • Chromo Helicases
  • Chromo Acetyltransferases
  • CHROMO SHADOW DOMAIN
  • NUCLEIC ACID-BINDING CHROMO DOMAINS
  • POSTTRANSLATIONAL MODIFICATIONS AND CHROMO DOMAIN TRANSACTIONS
  • Posttranslational Modifications of Chromo Domain Proteins
  • Histone Phosphorylation and Chromo Domain Binding
  • TARGETING CHROMO DOMAINS FOR THERAPEUTICS
  • CHROMO DOMAIN ASSOCIATION WITH HUMAN DISEASE
  • Evidence for a Role of Chromo Domain Ligands and Their Writers in Cancer Biology
  • Impact of Chromo Domain Proteinsin Carcinogenesis
  • CONCLUSION
  • List of Acronyms and Abbreviations
  • Acknowledgments
  • References
  • 7 - The Role of PHD Fingers in Chromatin Signaling: Mechanisms and Functional Consequences of the Recognition of Hi ...
  • INTRODUCTION
  • THE HISTORY OF THE PLANT HOMEODOMAIN FINGER
  • THE STRUCTURAL BASIS OF HISTONE RECOGNITION
  • Specific Recognition of H3K4me3
  • Specific Recognition of H3K4me0
  • Specific Recognition of H3K9me3
  • Specific Recognition of H3K14ac
  • THE MECHANISM OF PLANT HOMEODOMAIN FINGERS IN THE COMBINATORIAL READOUT OF PATTERNS OF HISTONE POST-TRANSLATIONAL MODIFICATIONS
  • Methods for Screening Histone Post-Translational Modification Recognition and Cross-Talk
  • Histone Post-Translational Modification Cross-Talk Mediated by a Single Plant Homeodomain Finger
  • Plant Homeodomain Fingers in Multivalent Histone Binding
  • In Cis Multivalent Interactions
  • In Trans Multivalent Interactions
  • NON-HISTONE TARGETS
  • Non-Histone Protein Targets of Plant Homeodomain Fingers
  • Nucleic Acids, Phosphoinositides, and Unknown Targets of Plant Homeodomain Fingers
  • UNDERSTANDING THE ROLE OF THE PLANT HOMEODOMAIN FINGER IN THE FUNCTION OF ITS HOST PROTEIN
  • Targeting and Retention at Chromatin
  • Regulation of Enzymatic Activity
  • PLANT HOMEODOMAIN FINGERS IN DISEASE
  • Plant Homeodomain Fingers in Cancer
  • Plant Homeodomain Fingers in Developmental and Neurological Disorders
  • Plant Homeodomain Fingers in Immunological Disorders
  • The Potential of Plant Homeodomain Fingers as a Drug Target
  • CONCLUSION
  • References
  • 8 - Tudor Domains as Methyl-Lysine and Methyl-Arginine Readers
  • INTRODUCTION
  • THE AROMATIC CAGE: MOLECULAR BASIS OF METHYL-LYSINE AND METHYL-ARGININE RECOGNITION
  • TUDOR DOMAINS INTERACTING WITH METHYLATED LYSINE-CONTAINING PEPTIDES
  • Single Tudor Domain as Functional Unit for Recognition of Lysine Methylation
  • Single Tudor2 Domain of PHF20
  • Single Tudor Domains of PHF1 and PHF19
  • Tandem Tudor Domains as Functional Unit for Recognition of Lysine Methylation
  • Tandem Tudor Domains of 53BP1
  • Tandem Tudor Domains of SGF29
  • Tandem Tudor Domains of UHRF1
  • Tandem Tudor Domains of SHH1
  • Tandem Tudor Domains of Spindlin1
  • Hybrid Tudor Domains as Functional Unit for Recognition of Lysine Methylation
  • Hybrid Tudor Domains of JMJD2A
  • TUDOR DOMAINS INTERACTING WITH METHYLATED ARGININE-CONTAINING PEPTIDES
  • Single Tudor Domain as Functional Unit for Recognition of Arginine Methylation
  • Extended Tudor Domain as Functional Unit for Recognition of Arginine Methylation
  • CONCLUSION
  • Acknowledgments
  • References
  • III - HISTONE MARK ERASERS
  • 9 - Histone Deacetylases, the Erasers of the Code
  • INTRODUCTION
  • HISTONE MODIFICATIONS AND GENE TRANSCRIPTION
  • Model 1: The Untargeted Model
  • Model 2: The Generally Targeted Model
  • Model 3: Gene-Specific Targeting Model
  • HISTONE DEACETYLASE FAMILIES AND CLASSES
  • HISTONE DEACETYLASES STRUCTURES AND CATALYTIC MECHANISMS
  • HISTONE DEACETYLASES AS MODULATORS OF THE EPIGENOME
  • HISTONE DEACETYLASES BIOLOGY
  • CONCLUSION
  • List of Abbreviations
  • References
  • 10 - Lysine Demethylases: Structure, Function, and Disfunction
  • INTRODUCTION
  • FAMILIES: FUNCTIONAL AND STRUCTURAL FEATURES
  • Mechanism of Action: LSD Versus JMJC Catalytic Domains
  • Structural Domains
  • KDMs Specificity
  • Targeting
  • TRANSCRIPTIONAL OUTPUT AND REGULATION
  • PHYSIOLOGICAL ROLE
  • Main KDMs-Driven Phenotypes
  • Cellular and Molecular Mechanism Associated With the Role KDMs in Development
  • KDM-ASSOCIATED DISEASES
  • Neurological Diseases
  • KDMs and Tumorigenesis
  • Prostate Cancer
  • Breast Cancer
  • Neuroblastoma
  • KDM INHIBITORS AS NEW EPIGENETIC DRUGS
  • FAD-Dependent Amine Oxidases Inhibitors
  • JMJC-Type Oxygenases Inhibitors
  • CONCLUSION
  • Acknowledgments
  • References
  • IV - CHROMATIN SIGNALING
  • 11 - Variation, Modification, and Reorganization of Broken Chromatin
  • INTRODUCTION
  • HISTONE MODIFICATIONS IN DSB REPAIR
  • Overview
  • Histone Acetylation and Deacetylation
  • HATs, HDACs, and DSB Repair
  • Histone Methylation and Demethylation
  • Histone H3K36 Methylation and DSB Repair
  • Histone H3K9 Methylation and DSB Repair
  • HISTONE VARIANTS IN DSB REPAIR
  • H2A Variants
  • H2AX in DSB Repair
  • macroH2A in DSB Repair
  • H2A.Z in DSB Repair
  • Htz1 and DNA DSB Responses in Budding Yeast
  • H2A.Z and DNA DSB Responses in Higher Eukaryotes
  • CHROMATIN REMODELING ENZYMES IN DSB REPAIR
  • Snf2 Subfamily
  • Mi2-NuRD Subfamily
  • Iswi Subfamily
  • ALC1 Subfamily
  • LSH Subfamily
  • CONCLUSION
  • References
  • 12 - Crosstalk Between Histone Modifications Integrates Various Signaling Inputs to Fine-Tune Transcriptional Output
  • INTRODUCTION
  • CROSSTALK BETWEEN HISTONE MODIFICATIONS AND THEIR CONSEQUENCES
  • HISTONE MARKS AND RECRUITMENT OF CHROMATIN FACTORS
  • HISTONE LYSINE METHYLATION AND ACETYLATION
  • HISTONE UBIQUITINATION AND METHYLATION: A TRANS EFFECT
  • Transcriptional Bivalency
  • HISTONE PHOSPHORYLATION
  • Histone Crosstalk by H3S10ph Exhibits a Common Paradigm of Gene Activation
  • HISTONE-MODIFYING COMPLEXES HAVE MULTIPLE CATALYTIC ROLES AND FUNCTIONS
  • MLL/COMPASS Complex
  • SAGA Complex
  • PRC Complex
  • SWI/SNF Complex
  • Heterochromatin-Associated Complexes
  • HISTONE ARGININE METHYLATION
  • HISTONE TAIL CLEAVAGE EXHIBITS THE ULTIMATE IRREVERSIBLE REMOVAL OF HISTONE MODIFICATIONS
  • HISTONE MODIFICATION AT ENHANCERS
  • CONCLUSION
  • List of Acronyms and Abbreviations
  • Glossary
  • References
  • 13 - Signaling and Chromatin Networks in Cancer Biology
  • INTRODUCTION
  • REGULATION OF EPITHELIAL-MESENCHYMAL-TRANSITION
  • CHROMATIN REMODELING IN THE REGULATION OF CANCER CELL PLASTICITY
  • THE EPITHELIAL-MESENCHYMAL-TRANSITION TRANSCRIPTION FACTOR MACHINERY
  • THE ROLE OF POSTTRANSCRIPTIONAL REGULATION OF EPITHELIAL-MESENCHYMAL-TRANSITION
  • PERSPECTIVE
  • References
  • V - CHROMATIN DYNAMICS IN NORMAL AND DISEASE CONDITIONS
  • 14 - Crosstalk Between DNA Methylation and Chromatin Structure
  • INTRODUCTION
  • Introduction to DNA Methylation
  • DNA Methylation Variants: 5mC, 5hmC, 5fC, and 5caC
  • DNA Methylation Enzymes
  • Regulation of DNA Methylation
  • CROSSTALK BETWEEN DNA METHYLATION AND CHROMATIN STRUCTURE
  • Readers of DNA Methylation Marks: Methyl-Binding Proteins
  • MeCP2
  • Histone Lysine Methyltransferases
  • mCpG Zinc Finger Domain Binding Proteins
  • mCpG SRA Binding Domain: UHRF1-UHRF2
  • Histone Modifiers Recruited to Methylated DNA: Histone Acetyltransferases (HAT) and Histone Deacetylases (HDAC)
  • Histone Acetyltransferases
  • Histone Deacetylases
  • Chromatin Remodelers Recruited by MBPs: NuRD Transcriptional Repressor Complex
  • SIGNIFICANCE OF ALTERED DNA-CHROMATIN CROSSTALK IN DISEASE
  • CONCLUSIONS
  • List of Abbreviations
  • References
  • 15 - Epigenetic Regulation of Endoplasmic Reticulum Stress
  • INTRODUCTION
  • Response to Endoplasmic Reticulum Stress: The Unfolded Protein Response
  • Unfolded Protein Response Signaling
  • PERK Signaling
  • ATF6 Signaling
  • IRE1a Signaling
  • The UPR Transcriptional Control Network
  • Non-Canonical Regulation of Transcription
  • Posttranslational Modifications and Transcription Factor Complexes in UPR-Induced Transcription
  • Crosstalk Between UPR and Other Signaling Pathways
  • ER Stress Posttranscriptional Signaling Networks
  • Gene Regulation by RIDD
  • Gene Regulation by miRNAs
  • Transcription Factor Complex Recruitment and Chromatin Modifications in the UPR
  • Relevance of ER Stress-Induced Transcription in Diseases
  • Cancer
  • Neurodegenerative Disorders
  • Inflammatory and Metabolic Diseases
  • CONCLUSIONS
  • Acronyms
  • Acknowledgments
  • References
  • 16 - Chromatin Signaling in Aging and Cellular Senescence
  • AGING, CELLULAR SENESCENCE, AND CHROMATIN: AN INTRODUCTION
  • Cellular Senescence
  • How Does Cellular Senescence Affect Aging?
  • Model Systems for the Study of Senescence and Aging
  • The Chromatin/Aging Connection
  • NUCLEOSOMAL MODIFICATIONS IN SENESCENCE AND AGING
  • Histone Levels and Histone Occupancy
  • Incorporation of Histone Variants
  • Nucleosome Remodeling
  • Overview
  • HISTONE POSTTRANSLATIONAL MODIFICATIONS DURING CELLULAR SENESCENCE AND AGING
  • Global Histone Modifications Associated With Cellular Senescence and Aging
  • Overview
  • Expression of Chromatin Modifiers in Senescence
  • Oncogene Activation and Senescence-Associated Heterochromatin Foci Formation
  • Genomic Loci Affected by Aging- and Senescence-Dependent Chromatin Modifications
  • INK4A/ARF Locus
  • rDNA Locus
  • Lamin-Associated Domains and Nuclear Architecture
  • MODULATION OF LIFESPAN BY EXPERIMENTAL ALTERATION OF CHROMATIN MODIFIERS IN ANIMAL MODELS
  • Histone Acetylation
  • Histone Methylation
  • Connection to Known Lifespan Determining Pathways and Molecular Targets
  • Non-histone Targets
  • Inheritance of Longevity
  • AGE-DEPENDENT REGULATION OF THE CHROMATIN-METABOLISM CONNECTION
  • Mitochondrial Dysfunction and ROS Production in Senescence
  • ROS Production and DNA Damage Response in Senescence
  • Mitochondrial Metabolism Impact Chromatin Modifiers Activity
  • EFFECT OF TELOMERE SHORTENING ON TELOMERIC CHROMATIN
  • Alterations of Telomere Length During Aging and Cellular Senescence
  • Chromatin Structure at the Telomeric Region
  • CONCLUSION
  • List of Acronyms and Abbreviations
  • References
  • 17 - Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells
  • INTRODUCTION
  • NUCLEAR ARCHITECTURE
  • Enhancers and Super-Enhancers
  • CHROMATIN STRUCTURE
  • HISTONE MODIFICATIONS AND VARIANTS
  • CHROMATIN REMODELING
  • Histone Lysine Methyltransferases and Demethylases
  • Histone Acetyltransferases (HATs) and Deacetylases (HDACs)
  • ATP-Dependent Chromatin-Remodeling Complexes
  • SWI/SNF
  • ISWI
  • Mi-2/NURD
  • INO80
  • CHROMATIN DYNAMICS DURING EMBRYO DEVELOPMENT
  • CHROMATIN DYNAMICS DURING LINEAGE DIFFERENTIATION
  • CANCER STEM-LIKE CELLS: HISTORICAL PERSPECTIVE
  • EPIGENETIC FACTORS REGULATING TUMORIGENESIS AND CANCER STEM CELLS
  • DNA Methylation in CSCs
  • HISTONE MODIFICATIONS AND VARIANTS IN CSCS
  • CHROMATIN REMODELING IN CSCS
  • Histone Lysine Methyltransferases and Demethylases in CSCs
  • Histone Acetyltransferases (HATs) and Deacetylases (HDACs) in CSCs
  • ATP-Dependent Chromatin-Remodeling Complexes in CSCs
  • CONCLUSION
  • References
  • 18 - Altered Chromatin Signaling in Cancer
  • INTRODUCTION
  • EPIGENETIC READERS
  • BET Family of Chromatin Adaptors
  • POLYCOMB AND TRITHORAX
  • Polycomb Repressive Complex 2
  • Regulation of PRC2 Target Recognition
  • Polycomb Repressive Complex 1
  • Trithorax
  • Chromatin Remodelers
  • METABOLIC REGULATION OF EPIGENETIC SIGNALING
  • CONCLUSION
  • References
  • 19 - Impact of Chromatin Changes in Pathogenesis of Infectious Diseases: A Pathogen View
  • PARASITES
  • Metamonads
  • Epigenetic Mechanism Underlying Antigenic Variation and Encystation in Giardia lamblia
  • Apicomplexa
  • Role of Acetylation, Deacetylation, Methylation, and Succinylation of Histones During Toxoplasma gondii Life Cycle
  • Involvement of Histone Modifications in Survival Mechanisms in the Parasite Plasmodium falciparum
  • Kinetoplastids
  • Epigenetic Machinery in Trypanosoma brucei
  • Chromatin Modifiers Are Present in Trypanosoma cruzi
  • YEAST
  • Outline placeholder
  • Studies of Epigenetic Mechanisms Utilized by Candida albicans
  • Production of Fungal Secondary Metabolites Are Epigenetically Regulated in Aspergillus
  • Protective Mechanisms in Cryptococcus Involve the Participation of Chromatin Modifications
  • CONCLUSION
  • References
  • 20 - Chromatin Remodeling and Epigenetic Reprogramming in Chronic Disease and Cancer in the Liver and Pancreas
  • INTRODUCTION
  • DEVELOPMENT OF PANCREAS AND LIVER
  • EPIGENETICS OF LIVER DISEASES
  • Contributions of Liver to Systemic Epigenetic Regulation
  • Liver Pathology
  • Chromatin Dynamics in Liver Fibrosis
  • Nonalcoholic Fatty Liver Disease
  • Alcoholic Liver Disease
  • Hepatocellular Carcinoma
  • EPIGENETICS OF PANCREATIC DISEASES
  • Diabetes
  • Pancreatitis
  • Pancreatic Cancers
  • Cystic Fibrosis and the CFTR Gene
  • FUTURE DIRECTIONS: CLINICAL POTENTIAL OF TARGETING CHROMATIN-REMODELING PROTEINS
  • Diagnostics
  • Therapy
  • Acknowledgments
  • References
  • 21 - Pharmacological and Therapeutic Targeting of Epigenetic Regulators
  • INTRODUCTION
  • TARGETING THE DNA METHYLATION PATHWAY
  • THE RNA WORLD
  • HISTONE ACETYLASES AND DEACETYLASES
  • HISTONE METHYLASES AND DEMETHYLASES
  • CHROMATIN READERS
  • CONCLUDING REMARKS
  • References
  • 22 - Use of Chromatin Changes as Biomarkers
  • INTRODUCTION
  • Epigenetic Changes as Biomarkers of Human Disease
  • Biomarker Subtypes
  • Diagnostic
  • Prognostic
  • Therapeutic Response
  • Effects of Sensitivity and Specificity
  • Tissue Surrogate Epigenetic Biomarkers
  • CONCEPT 1: ALTERED DNA METHYLATION LANDSCAPES AS BIOMARKERS OF HUMAN DISEASE
  • Cancer
  • Diagnosis
  • Prognosis
  • Therapeutic Response
  • Psychiatric Disorders
  • Imprinting Disorders
  • CONCEPT 2: ABERRANT MICRORNA EXPRESSION IN DISEASE STATES
  • Cancer
  • Diagnosis
  • Prognosis
  • Therapeutic Response
  • Diabetes
  • Psychiatric Disorders
  • CONCEPT 3: DISEASE-SPECIFIC HISTONE POSTTRANSLATIONAL MODIFICATIONS FUNCTION AS BIOMARKERS
  • Cancer
  • Diagnosis
  • Prognosis
  • Other Diseases
  • CONCEPT 4: TISSUE SURROGATE EPIGENETIC BIOMARKERS
  • Blood
  • Stool
  • Other Tissues
  • CONCLUSION
  • Challenges
  • Future Directions
  • List of Acronyms and Abbreviations
  • Glossary
  • Acknowledgments
  • References
  • 23 - Regulation of Host Chromatin by Bacterial Metabolites
  • INTRODUCTION
  • THE COMMENSAL BACTERIAL METABOLOME
  • DIETARY CARCINOGENS ALTER CHROMATIN
  • BILE ACIDS: MICROBIAL BILE-OME AND NUCLEAR RECEPTORS
  • ESTROGENS: MICROBIAL ESTRABOLOME AND CHROMATIN MODULATION
  • ELLAGIC ACID AND HISTONES METHYLATION
  • SHORT CHAIN FATTY ACIDS (SCFAS), G PROTEIN-COUPLED RECEPTORS, AND HISTONE DEACETYLASES
  • INDOLES AND NUCLEAR RECEPTORS
  • POLYKETIDES
  • BACTERIAL NUCLEOMODULINS
  • MISCELLANEOUS
  • NON-MAMMALIAN SYSTEMS
  • PLANTS
  • LESSONS TO APPLY FROM HOST INTERMEDIARY METABOLISM AND CHROMATIN
  • METABOLITE MINING FOR CHROMATIN MODULATION
  • CONCLUSION
  • List of Acronyms and Abbreviations
  • References
  • Index
  • A
  • B
  • C
  • D
  • F
  • H
  • I
  • J
  • M
  • N
  • O
  • P
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Back Cover

Dateiformat: EPUB
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat EPUB ist sehr gut für Romane und Sachbücher geeignet - also für "fließenden" Text ohne komplexes Layout. Bei E-Readern oder Smartphones passt sich der Zeilen- und Seitenumbruch automatisch den kleinen Displays an. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Dateiformat: PDF
Kopierschutz: Adobe-DRM (Digital Rights Management)

Systemvoraussetzungen:

Computer (Windows; MacOS X; Linux): Installieren Sie bereits vor dem Download die kostenlose Software Adobe Digital Editions (siehe E-Book Hilfe).

Tablet/Smartphone (Android; iOS): Installieren Sie bereits vor dem Download die kostenlose App Adobe Digital Editions (siehe E-Book Hilfe).

E-Book-Reader: Bookeen, Kobo, Pocketbook, Sony, Tolino u.v.a.m. (nicht Kindle)

Das Dateiformat PDF zeigt auf jeder Hardware eine Buchseite stets identisch an. Daher ist eine PDF auch für ein komplexes Layout geeignet, wie es bei Lehr- und Fachbüchern verwendet wird (Bilder, Tabellen, Spalten, Fußnoten). Bei kleinen Displays von E-Readern oder Smartphones sind PDF leider eher nervig, weil zu viel Scrollen notwendig ist. Mit Adobe-DRM wird hier ein "harter" Kopierschutz verwendet. Wenn die notwendigen Voraussetzungen nicht vorliegen, können Sie das E-Book leider nicht öffnen. Daher müssen Sie bereits vor dem Download Ihre Lese-Hardware vorbereiten.

Weitere Informationen finden Sie in unserer E-Book Hilfe.


Download (sofort verfügbar)

128,52 €
inkl. 19% MwSt.
Download / Einzel-Lizenz
ePUB mit Adobe DRM
siehe Systemvoraussetzungen
PDF mit Adobe DRM
siehe Systemvoraussetzungen
Hinweis: Die Auswahl des von Ihnen gewünschten Dateiformats und des Kopierschutzes erfolgt erst im System des E-Book Anbieters
E-Book bestellen

Unsere Web-Seiten verwenden Cookies. Mit der Nutzung des WebShops erklären Sie sich damit einverstanden. Mehr Informationen finden Sie in unserem Datenschutzhinweis. Ok