Sites of Drug Action in the Human Brain uses the results of recent analyses of the regional brain distribution and binding pattern of drugs in the human brain. This new book specifically addresses drugs of abuse and treats the effects of various drugs on behavior and mood, as well as on metabolism and blood flow in the human brain. It also presents the methodological aspects of investigating the sites of drug action in the human brain.
Because it focuses on the living human brain, this book differs from other books on the subject, which primarily use the results of postmortem studies. Sites of Drug Action in the Human Brain therefore provides valuable information on the clinical aspects of drug intoxification, addiction, and toxicity.
Anat Biegon, Ph.D. is Head of Research Development at Pharmos Corp. Before joining the industry, she held research posts t the Weizmann Institute of Science, New York University medical school and Lawrence Berkeley Laboratory. Dr. Biegon was involved in the development of the technique of quantitative autoradiography and was among the first to apply this technique to the study of receptors and drug binding sites in the human brain post-mortem. Dr. Biegon has authored more than 80 papers on various aspects of drug receptor localization and regulation in the brain. Nora D. Volkow, M.D. is Director of Nuclear Medicine and Associate Chief of Staff, Medical Department, Brookhaven National Laboratory. She is also Associate Professor at the Department of Psychiatry at SUNY-Stony Brook. She was the pioneer on the use of Nuclear medicine Techniques for the investigation of drugs of abuse. She has authored more than 110 research papers as well as more than 40 chapters and paper reviews on the applications of positron emission tomography in psychiatry, substance abuse and pharmacology.
Chapter 1. Localization and Characterization of Drug Binding Sites in the Human Brain: Methodological Considerations, Chapter 2. Autoradiographic Localization of Benzodiazepine Receptor in the Human Brain Post-Mortem, Chapter 3. In Vivo Imaging of Benzodiazepine Receptors with Positron Emission Tomography, Chapter 4. Effects of Benzodiazepine on Behavior, Mood, and Regional Cerebral Metabolism, Chapter 5. Quantitative Autoradiography and Cannabinoid Receptors in the Human Brain Post-Mortem, Chapter 6. The Effects of Marihuana in the Human Brain Measured with Regional Brain Glucose Metabolism Nora D. Volkow, Hampton Gillespie, Lawrence Tancredi, and Leo Hollister, Chapter 7. Quantitative Autoradiographic Localization and Characterization of Cocaine Binding Sites in the Human Brain Post-Mortem, Chapter 8. PET Studies of Cocaine in Human Brain, Chapter 9. Autoradiographic Distribution of Multiple Opioid, Sigma, and Phencyclidine Receptor Binding Sites in the Human Brain, Chapter 10. Imaging Opiate Receptor In Vivo, Chapter 11. The Use of Positron Emission Tomography to Study the Acute Effects of Addictive Drugs on Cerebral Metabolis, Discussion, Index