Lessons in Immunity

From Single-cell Organisms to Mammals
 
 
Academic Press
  • 1. Auflage
  • |
  • erschienen am 8. April 2016
  • |
  • 324 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-803253-4 (ISBN)
 

Lessons in Immunity: From Single-cell Organisms to Mammals stems from the activity of the Italian Association of Developmental and Comparative Immunobiology (IADCI), represented by the editors. This book is presented as a series of short overviews that report on the current state of various relevant fields of immunobiology from an evolutionary perspective. The overviews are written by authors directly involved in the research, and most are members of the IADCI or have otherwise been involved in the related research for their respective overview. This publication offers scientists and teachers an easy and updated reference tool.


  • Provides simple and updated reviews on the immunobiology of a wide spectrum of organisms, considered in an evolutionary context
  • Focuses on both cells and humoral components of a variety of non-classical model organisms
  • Offers in a single volume many contributions which can help with understanding the evolution of immune responses and the main adaptations in animal phyla
  • Presents a valuable holistic cross-sectional approach for teaching immunology and its applications
  • Englisch
  • San Diego
  • |
  • USA
Elsevier Science
  • 5,27 MB
978-0-12-803253-4 (9780128032534)
0128032537 (0128032537)
weitere Ausgaben werden ermittelt
  • Front Cover
  • Lessons in Immunity: From Single-Cell Organisms to Mammals
  • Lessons in Immunity: From Single-Cell Organisms to Mammals
  • Copyright
  • Contents
  • List of Contributors
  • Preface
  • 1 - Ciliate Pheromones: Primordial Self-/Nonself-Recognition Signals
  • INTRODUCTION
  • PHEROMONE IDENTIFICATION
  • PHEROMONE STRUCTURES
  • PHEROMONE ACTIVITY
  • PHEROMONE STRUCTURE-FUNCTION RELATIONSHIPS WITH OTHER SIGNALING PROTEINS
  • CONCLUSIONS
  • REFERENCES
  • 2 - Cell Death Pathways in an Unconventional Invertebrate Model
  • INTRODUCTION
  • SIGNALING PATHWAYS IN APOPTOTIC CELL DEATH OF THE IPLB-LDFB INSECT CELL LINE
  • AUTOPHAGY-MEDIATED CELL DEATH IN IPLB-LDFB
  • CONCLUDING REMARKS
  • REFERENCES
  • 3 - Immunotoxicology Approaches in Ecotoxicology: Lessons From Mollusks
  • MOLLUSK HEMOCYTES: TYPES AND FUNCTIONS
  • INTERACTION BETWEEN HEMOCYTES AND TOXICANTS: THE IMMUNOMARKER APPROACH
  • MOLLUSK IMMUNOMARKERS: THE ROLE OF CONFOUNDING FACTORS
  • REFERENCES
  • 4 - New Aspects of Earthworm Innate Immunity: Novel Molecules and Old Proteins With Unexpected Functions
  • ESSENTIALS OF EARTHWORM IMMUNITY: A CONCISE INTRODUCTION
  • Earthworms as a Research Model in Life Sciences
  • Historical Foundation of Earthworm Immunity Research
  • Major Constituents of Earthworm Immune Response
  • "STARS AND STRIPES" OR PATTERN RECOGNITION IN EARTHWORMS
  • Coelomic Cytolytic Factor: The Unique Earthworm Pattern Recognition Receptors
  • Variations on a Theme: Not Just Coelomic Cytolytic Factor Anymore
  • Toll-like Receptors Expression in Nonimmune Tissues
  • LYSENIN: A MULTITASKING PROTEIN IN EISENIA EARTHWORMS
  • Cellular Expression of Lysenin
  • Antimicrobial Induction of Lysenin
  • Inhibitors and Possible Regulators of Lysenin-Mediated Cell Lysis
  • LYSENIN MEETS NANOPARTICLES: UNEXPECTED RISE OF A NEW FUNCTION
  • Lysenin and the Concept of the Biomolecular Corona
  • The High Affinity of Lysenin for Silver Nanoparticles
  • The Unexpected Role of Lysenin in the Accumulation of Nanoparticles
  • CONCLUSIONS AND PERSPECTIVES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 5 - Neuroprotection and Immunity in the Medicinal Leech Hirudo medicinalis: What About Microglia?
  • THE MEDICINAL LEECH CENTRAL NERVOUS SYSTEM
  • MICROGLIA AS BRAIN IMMUNE CELLS
  • IMMUNE RESPONSE AGAINST PATHOGENS
  • MICROGLIA RECRUITMENT
  • NEUROINFLAMMATORY MARKERS
  • TOWARD NERVE REPAIR: MICROGLIA/NEURONS CROSSTALK INTO THE SPOTLIGHT
  • CONCLUSIONS
  • REFERENCES
  • 6 - Specificity of Innate Immunity in Bivalves: A Lesson From Bacteria
  • INNATE IMMUNITY IN BIVALVES: DIVERSITY AND COMPLEXITY
  • BIVALVES AND MARINE BACTERIA
  • IMMUNE RECOGNITION
  • IMMUNE SIGNALING
  • IMMUNE EFFECTORS
  • SPECIFICITY OF THE IMMUNE RESPONSE TO PATHOGENIC VIBRIOS: ROLE OF SURFACE INTERACTIONS AND SERUM-SOLUBLE COMPONENTS
  • CONCLUSIONS
  • REFERENCES
  • 7 - Immune-Related Signaling in Mussel and Bivalves
  • PREMISE
  • MULTIPLE LAYERS OF BIOLOGICAL SIGNALING
  • IMMUNE SIGNALING AND RELATED CELL PROCESSES
  • HOW SMALL RNAS CAN INFLUENCE THE IMMUNE HOST RESPONSE
  • PERSPECTIVES
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 8 - Crustacean Immunity: The Modulation of Stress Responses
  • SOURCES OF STRESS
  • INDICATORS OF STRESS
  • STRESS RESPONSES MEDIATED BY NEUROPEPTIDES
  • UPSTREAM MODULATORS TRIGGERING CHHS
  • THE CRUSTACEAN HYPERGLYCEMIC HORMONE NEUROPEPTIDES
  • PERSPECTIVES
  • REFERENCES
  • 9 - How Insects Combat Infections
  • CHARACTERISTICS OF INSECT IMMUNE RESPONSE
  • Antibacterial and Antifungal Response
  • Recognition of Infection
  • Peptidoglycan Recognition Protein Family
  • GNBP/ß-GRP Family
  • Down Syndrome Cell Adhesion Molecule
  • Signaling Pathways
  • Toll and Imd Pathways
  • JAK/STAT Pathway
  • Antiviral Response
  • Specificity of Immune Response, Memory, and Immune Priming
  • INTERACTION BETWEEN INSECT HOST AND PATHOGEN
  • Getting Into the Insect Body
  • Inside the Hemocoel
  • REFERENCES
  • 10 - Aedes aegypti Immune Responses to Dengue Virus
  • INTRODUCTION
  • TRANSMISSION TO HUMAN HOSTS: VECTORS
  • DENGUE VIRUS IN THE VECTOR: INNATE IMMUNE RESPONSES
  • Toll Pathway
  • Immune Deficiency Pathway
  • Janus Kinase-Signal Transducer and Activator of Transcription Pathway
  • RNA Interference
  • Autophagy
  • Apoptosis
  • Interactions Among Pathways
  • Dengue Virus in the Vector: Midgut Microbes
  • Vector Competence: Refractory and Susceptible A. aegypti Phenotypes
  • Refractory A. aegypti
  • MITIGATING DENGUE: CONTROL MEASURES
  • CONCLUSION
  • REFERENCES
  • 11 - Protective Responses in Invertebrates
  • BACKGROUND
  • MEDIATORS OF IMMUNE RESPONSES
  • DEGREE OF INTERCELLULAR REACTIVE OXYGEN SPECIES LEVELS AND IMMUNE RESPONSES
  • PROPHENOL OXIDASE SYSTEM ACTIVATION
  • CELLULAR RESPONSES
  • EMERGING CONCEPTS ABOUT NEW PLAYERS INVOLVED IN PROTECTIVE RESPONSES
  • REFERENCES
  • 12 - Echinoderm Antimicrobial Peptides: The Ancient Arms of the Deuterostome Innate Immune System
  • INTRODUCTION
  • ECHINODERM IMMUNITY
  • ANTIMICROBIAL PEPTIDES
  • MODE OF ACTION
  • ANTIMICROBIAL PEPTIDES IN ECHINODERMS
  • ANTIMICROBIAL BIOFILM PEPTIDES IN ECHINODERMS
  • CONCLUSION
  • REFERENCES
  • 13 - Inflammatory Response of the Ascidian Ciona intestinalis
  • INTRODUCTION
  • SELF/NONSELF RECOGNITION
  • INFLAMMATORY RESPONSES
  • Inflammatory Reaction in the Tunic
  • Encapsulation
  • THE PHARYNX IS PROMPTLY INVOLVED IN THE INFLAMMATORY REACTION
  • C-Type Lectins
  • CD94
  • Lectin-Dependent Complement Pathway
  • Galectins
  • Cytokines
  • Prophenoloxidase
  • Fibril-Associated Collagen With Interrupted Triple Helix-Like Collagen
  • Catabolite Activator Protein
  • CONCLUSIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 14 - Cytotoxic Cells of Compound Ascidians
  • INTRODUCTION
  • ASCIDIAN CIRCULATION
  • HEMOCYTES OF COMPOUND ASCIDIANS
  • CYTOTOXIC CELLS
  • CYTOTOXICITY
  • PHENOLOXIDASE
  • ALLORECOGNITION AND INFLAMMATION
  • IMMUNORECOGNITION AND IMMUNOMODULATION
  • FUTURE PERSPECTIVES: NEW ROLES FOR OLD CELLS
  • REFERENCES
  • 15 - Fish Transcriptomics
  • INTRODUCTION
  • TRANSCRIPTOMICS ANALYSIS OF FISH LEUKOCYTES
  • Physiological Processes
  • Parasite Response
  • Transcripts in Specific Tissues
  • Bacterial Infection
  • Virus Infection
  • Evolution Biology
  • CONCLUSION
  • REFERENCES
  • 16 - Developmental Biology of Teleost Lymphocytes
  • INTRODUCTION
  • T CELL DEVELOPMENT
  • B CELL DEVELOPMENT
  • PERSPECTIVES
  • REFERENCES
  • 17 - Cathelicidins: An Ancient Family of Fish Antimicrobial Peptides
  • THE PRESENCE OF CATHELICIDIN IN BONY FISH GENOMES
  • STRUCTURE OF CATHELICIDIN GENE AND TRANSCRIPTS
  • Cathelicidin Gene Expression
  • Protein Processing and Expression
  • Biological Activity of the C-Terminal Peptides
  • CONCLUSIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 18 - Evolution and Immune Function of Fish Lectins
  • INTRODUCTION
  • FISH LECTINS
  • THE LECTIN REPERTOIRES IN FISH: GENOMIC, STRUCTURAL, AND FUNCTIONAL DIVERSITY
  • RHAMNOSE-BINDING LECTINS
  • RHAMNOSE-BINDING LECTINS IN FISH: BIOCHEMICAL AND MOLECULAR FEATURES
  • RHAMNOSE-BINDING LECTIN-MOLECULAR STRUCTURE, PHYLOGENY, AND EVOLUTION
  • FUCOSE-BINDING LECTINS
  • FISH FTLS: BIOCHEMICAL AND MOLECULAR FEATURES
  • F-TYPE LECTINS-PHYLOGENY AND EVOLUTION
  • GALECTIN STRUCTURE AND EVOLUTION
  • C-TYPE LECTINS
  • MANNOSE-BINDING LECTINS IN FISH
  • MANNOSE-BINDING LECTIN PHYLOGENY AND EVOLUTION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 19 - Teleost Immunoglobulins
  • INTRODUCTION
  • TELEOST IGM
  • TELEOST IGD
  • TELEOST IGT
  • TELEOST IGL CHAIN
  • CONCLUSIONS
  • REFERENCES
  • 20 - Immunity and Wound Healing: Regeneration or Repair?
  • INTRODUCTION
  • INJURY-INDUCED INFLAMMATION AND ITS REGULATION DURING TISSUE REPAIR IN DIVERSE MODEL ORGANISMS
  • INFLAMMATION IS NOT ALL BAD FOR REPAIR
  • THE RELATIONSHIP BETWEEN IMMUNE SYSTEM DEVELOPMENT AND REGENERATIVE CAPACITY
  • ROLE OF LYMPHOCYTES IN REPAIR MECHANISMS
  • CONCLUSION
  • REFERENCES
  • 21 - Marine Mammal Immunity Toward Environmental Challenges
  • ADAPTATION OF MAMMALS TO THE MARINE ENVIRONMENT
  • MARINE MAMMALS, SENTINELS FOR THE HEALTH OF THE ECOSYSTEM
  • IMMUNOTOXIC EFFECTS OF ENVIRONMENTAL CHALLENGES
  • MOLECULAR EFFECTS OF ENVIRONMENTAL CHANGES ON MARINE MAMMAL IMMUNITY
  • REFERENCES
  • Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z
  • Back Cover

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