This text provides a comprehensive review of pathophysiology, molecular and cell biology aspects of CRPC, discusses all major clinical trials that have led to approval of 6 new drugs since 2004, explores the role of bone preservation strategies, in depth analysis of combination and sequencing strategies, outlines upcoming novel drugs and trends in research, and stresses the role of palliative care in this incurable disease. Managing Metastatic Prostate Cancer in Your Urological Oncology Practice will serve as a very useful resource for physicians and researchers dealing with, and interested in prostate cancer. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and will include the most up to date scientific and clinical information.
K.C. Balaji, MD
Chief of Urology, W.G. (Bill) Hefner VA Medical Center, Salisbury, North Carolina
Professor of Urology and Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina
Department of Urology, Cancer Biology, Institute of Regenerative Medicine
Wake Forest University School of Medicine, W.G. (Bill) Hefner VA Medical Center
Winston Salem, NC, USA
Mailing Address:
Department of Urology, Medical Center Blvd,
Winston Salem, NC 27157
T: 336 716 5690
F: 336 716 5711
Email: kbalaji@wakehealth.edu
Table of Contents
"Castration Resistant Prostate Cancer"
Editors: K.C Balaji
Ch. 1: Introduction
K.C Balaji
Ch. 2: Pathophysiology of Castration-Resistant Prostate Cancer
Justin C. Penticuff
Natasha Kyprianou
Ch. 3: Androgen Receptor Signaling in Castration Resistant Prostate Cancer
Yu Zhao
Donald J. Tindall
Haojie Huang
Ch. 4: Non-Androgen Signaling Pathways in Castration-Resistant Prostate Cancer
Sivanandane Sittadjody
Thilakavathy Thangasamy
Bita NickKolgh
K.C. Balaji
Ch. 5: Predictive Models in Castration Resistant Prostate Cancer
Tao Cui
Michael W. Kattan
Ch. 6: Docetaxel in Advanced and Castration Resistant Prostate Cancer
Daniel P. Petrylak
Navid Hafez
Ch. 7: Combination Treatment Strategies with Docetaxel in Patients with Metastatic Prostate
Ben Fulton
Robert J. Jones
Ch. 8: Cancer Vaccines in Castration Resistant Prostate Cancer - An evolution in design
Susan F. Slovin
Ch. 9: Abiraterone for the treatment of mCRPC
Zafeiris Zafeiriou
Niven Mehra
Johann S. de Bono
Ch. 10: Enzalutamide in Metastatic Castration Resistant Prostate Cancer
Jeffrey Shevach
Bridget K. Marcellino
William K. Oh
Che-Kai Tsao
Ch. 11: Radium-223 in Metastatic Castrate Resistant Prostate Cancer
Tu Dan
Robert B. Den
Ch. 12: Cabazitaxel for the Treatment of Prostate Cancer
Michael Kolinsky
Niven Mehra
Johann S. de Bono
Ch. 13: Sequencing Therapies in Metastatic Castration Resistant Prostate Cancer
Michael T. Schweizer
Bruce Montgomery
Ch. 14: Bone Preservation Strategies for Men on Androgen Deprivation Therapy
Charles C. Peyton
K. C. Balaji
Ch. 15: Novel Therapies in Castration-Resistant Prostate Cancer
Tyler Lash
Rhonda L. Bitting
