This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Miyuki AzumaTokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, Japan
Hideo YagitaJuntendo University School of Medicine, Dept of Immunology, Japan
Part I: Basic Understanding of Co-signal Molecules in T cell activation.- Chapter 1 Co-signal molecules in T cell activation.- Chapter 2 The CD28-B7 family of co-signaling molecules.- Chapter 3 The TNF YNFR family of co-signal molecules.- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors.- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation.- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation.- Chapter 7 Control of regulatory T cells by co-signal molecules.- Part II: Co-signal Molecules in Health and Disease.- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity.- Chapter 9 Co-signaling molecules in neurological diseases.- Chapter 10 Costimulation blockade in transplantation.- Chapter 11 Immunotherapy targeting co-signal molecules.