Studies in Natural Products Chemistry

Bioactive Natural Products (Part XIII)
 
 
Elsevier (Verlag)
  • 1. Auflage
  • |
  • erschienen am 30. September 2016
  • |
  • 434 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
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978-0-444-63756-7 (ISBN)
 

Studies in Natural Products Chemistry: Bioactive Natural Products (Part XIII) is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products.

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.


  • Focuses on the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • Presents sources of new pharmacophores
1572-5995
  • Englisch
  • Oxford
  • |
  • Niederlande
Elsevier Science
  • 13,73 MB
978-0-444-63756-7 (9780444637567)
0444637567 (0444637567)
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  • Front Cover
  • Studies in Natural Products Chemistry
  • Studies in Natural Products Chemistry
  • Copyright
  • Contents
  • Contributors
  • Foreword
  • Preface
  • 1 - Synthesis and Structure-Activity Relations in Allylsulfide and Isothiocyanate Compounds From Garlic and Broccoli Against In Vitro Cancer Cell Growth
  • BACKGROUND
  • GARLIC
  • THE CYTOTOXICITY OF GARLIC?ALLYLSULFUR COMPOUNDS IN?CANCER CELLS
  • Garlic Allylsulfur Compounds?as Glutathione Mimics
  • The Role of Glutathione in?the Cell
  • Garlic Allylsulfur Compounds?and the GSH:GSSG Ratio
  • Posttranslational Modification of Proteins by S-Glutathionylation
  • S-Glutathionylation in Cell Signaling
  • SYNTHETIC ROUTES TO GARLIC?ALLYLSULFUR COMPOUNDS AND THEIR DERIVATIVES
  • The Biosynthesis of Allicin in?the Plant
  • Polysulfanes
  • Dithiins
  • Ajoenes
  • STRUCTURE-ACTIVITY RELATIONS OF?GARLIC ALLYLSULFIDES AGAINST IN?VITRO CANCER CELL GROWTH
  • BROCCOLI
  • THE CYTOTOXICITY OF BROCCOLI ISOTHIOCYANATES IN CANCER CELLS
  • SYNTHETIC ROUTES TO BROCCOLI ISOTHIOCYANATES AND THEIR?DERIVATIVES
  • The Biosynthesis of?Glucosinolates in the Plant
  • Racemic Sulforaphane?Synthesis
  • Enantioselective Sulforaphane Synthesis
  • Sulforaphane-Isotopically?Labeled Synthesis
  • The Chemical Reactivity of Isothiocyanates in Cancer Cells
  • STRUCTURE-ACTIVITY RELATIONS OF ISOTHIOCYANATES AGAINST IN VITRO CANCER CELL GROWTH
  • Bifunctional Sulforaphane?Mimics
  • Monofunctional?Isothiocyanates
  • COMMONALITY IN THE ANTICANCER MECHANISMS OF ISOTHIOCYANATES?AND POLYSULFIDES IN CANCER CELLS
  • CONCLUSION
  • REFERENCES
  • 2 - Natural Products as Lead Protein Kinase C Modulators for Cancer Therapy
  • INTRODUCTION
  • ISOFORMS OF PROTEIN KINASE C FAMILY
  • Structure and Mechanisms of Regulation
  • Protein Kinase C and Carcinogenesis
  • PHORBOL ESTERS
  • BRYOSTATINS
  • STAUROSPORINE ANALOGS
  • INGENENE DITERPENES
  • MISCELLANEOUS AND PROMISING AGENTS
  • Daphnane Diterpenes
  • Abietane Diterpenoids
  • Phenolic Compounds
  • CONCLUDING REMARKS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 3 - Plant-Derived Prooxidants as Potential Anticancer Therapeutics
  • INTRODUCTION
  • TYPES OF REACTIVE OXYGEN SPECIES CAUSING OXIDATIVE STRESS
  • SOURCES OF CELLULAR REACTIVE?OXYGEN SPECIES
  • PHYSIOLOGICAL ROLE(S) OF REACTIVE OXYGEN SPECIES
  • ATTENUATION OF OXIDATIVE STRESS BY ANTIOXIDANTS
  • MODULATION OF REACTIVE OXYGEN SPECIES AND THE PATHOGENESIS?OF CANCERS
  • PROOXIDANTS AS POTENTIAL ANTICANCER COMPOUNDS
  • Prooxidant-Induced Apoptosis
  • IMPACT OF PROOXIDANTS UPON OXIDATIVE STRESS-RELATED?SIGNALING EVENTS
  • HOW DO PROOXIDANTS REGULATE?THE SIGNALING PATHWAYS?
  • Prosurvival Pathways
  • Phosphatidylinositide?3-Kinase/AKT Signaling Pathways
  • Redox Factor-1/Thioredoxin Signaling Pathways
  • Nuclear Factor Erythroid 2-Related Factor 2?Signaling Pathways
  • Nuclear Factor?Kappa-Light Chain?Enhancer of Activated B?Cell Signaling Pathways
  • Antisurvival Pathways
  • Mitogen-Activated?Protein Kinases Signaling Pathways
  • Reactive Oxygen Species?and DNA Damage?Response
  • CONCLUDING REMARKS
  • REFERENCES
  • 4 - Anticancer and Antineurodegenerative Effects of Ginsenosides
  • INTRODUCTION
  • ANTICARCINOGENIC FUNCTION?OF GINSENG
  • Antioxidation and Anti-Inflammation
  • Anticarcinogenic Activities,?Growth Inhibition, Death,?and Differentiation
  • Antimetastatic Effect and?Inhibition of Angiogenesis
  • Synergistic Effects of Ginseng?in Combination with?Therapeutic Drugs
  • Mass Production of?Ginsenosides Rh2 and Rg3
  • PROTECTIVE FUNCTION OF GINSENG AGAINST NEURODEGENERATIVE?DISEASES
  • Ginseng and Alzheimer's?Disease
  • Ginseng and Parkinson's?Disease
  • Comparison of the Effects of Ginsenosides Rb1 and Rg1 on Neurodegenerative Diseases
  • SUMMARY AND FURTHER RESEARCH
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 5 - Role of Phytochemicals in MAPK Signaling Pathway-Mediated Apoptosis: A Possible Strategy in Cancer Chemoprevention
  • INTRODUCTION
  • MAPK SIGNAL TRANSDUCTION?PATHWAYS
  • The Activation and Regulation?of ERK Signaling Pathway
  • The Effect of Phytochemicals on ERK Pathway in Cell?Apoptosis
  • The Activation and Regulation?of JNK Signaling Pathway
  • The Effect of Phytochemicals on JNK Pathway in Cell Apoptosis
  • The Activation and Regulation?of p38 Signaling Pathway
  • The Effect of Phytochemicals on p38 Pathway in Cell Apoptosis
  • CONCLUSION
  • ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 6 - Natural Products as Cathepsin Inhibitors
  • INTRODUCTION
  • FIRST CATHEPSINS INHIBITORS
  • E-64 AND DERIVATIVES
  • MIRAZIRIDINE A
  • TOKARAMIDE A
  • GALLINAMIDE A/SYMPLOSTATIN 4
  • GRASSYPEPTOLIDES
  • CYCLOHEXENYL INHIBITORS
  • BENZOPHENONE INHIBITORS
  • URSOLIC ACID
  • FLAVONOIDS
  • FLAVONOIDS AND TRITERPENES AS PARASITIC CATHEPSIN L INHIBITORS
  • ACRIDONES AS CATHEPSIN V?INHIBITORS
  • GRASSYSTATINS AS CATHEPSIN D?AND E INHIBITORS
  • INHIBITORS OF CATHEPSIN K
  • SUMMARY
  • REFERENCES
  • 7 - Endemic Plants of Italy and Their Peculiar Molecular Pattern
  • INTRODUCTION
  • ENDEMISM
  • BIODIVERSITY
  • Endemism: the Case?of Sardinia (Island Italy)
  • Genus Vinca
  • Genus Genista
  • Genus Euphrasia
  • Genus Linaria
  • Linaria arcusangeli
  • Linaria flava
  • Genus Stachys
  • Stachys corsica
  • Stachys glutinosa
  • Genus Teucrium
  • Genus Galium
  • Genus Helichrysum
  • Endemism: the Case of?Monti Sibillini National?Park (Peninsular Italy)
  • Genus Stachys
  • Stachys alopecuros subsp. divulsa
  • Stachys tymphaea
  • Genus Sideritis
  • REFERENCES
  • 8 - From Natural Products to Drugs: Glyco- and Lipoglycopeptides, a New Generation of Potent Cell Wall Biosynthesis Inhibitors
  • INTRODUCTION
  • THE GLYCOPEPTIDE FAMILY
  • Vancomycin
  • THE LIPOGLYCOPEPTIDE FAMILY
  • Teicoplanin
  • Ramoplanin
  • Telavancin
  • Dalbavancin
  • Oritavancin
  • CONCLUSION AND OUTLOOKS
  • ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 9 - CdH Bond Activation as a Powerful Tool in the Construction of Biologically Active Nitrogen-Containing Heterocycles
  • INTRODUCTION
  • FIVE-MEMBERED N-HETEROCYCLES
  • Pyrrole
  • Indole
  • Carbazole
  • Pyrazole and Indazole
  • Imidazole and Benzoimidazole
  • Thiazole and Oxazole
  • SIX-MEMBERED N-HETEROCYCLES
  • Pyridine
  • Quinoline and Isoquinoline
  • Cinnolines and Pyrazines
  • SMALL AND LARGE N-HETEROCYCLES
  • Three- and Four-Membered?Rings
  • Larger Rings
  • SUMMARY AND OUTLOOK
  • ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 10 - Isolation, Bioactivity, and Synthesis of Nagelamides
  • INTRODUCTION
  • BIOSYNTHETIC CONSIDERATIONS
  • Background
  • Optical Activity
  • SYNTHETIC STUDIES TOWARD THE NAGELAMIDES
  • Nagelamide E
  • Horne Synthesis of?Nagelamide D
  • Lovely Synthesis of?Nagelamide D
  • Nagelamide A
  • SYNTHETIC STUDIES TO NAGELAMIDE FRAGMENTS
  • Nagelamides C and S
  • Nagelamide K
  • Nagelamides R and T
  • CONCLUSIONS
  • ABBREVIATIONS
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 11 - Nutraceuticals Neuroprotect Naturally: Alzheimer's disease, Parkinson's disease, Stroke and Major Depressive Disorder
  • INTRODUCTION
  • ALZHEIMER'S DISEASE
  • Neuronal Regenerators
  • Cholinesterase Inhibitors
  • Anti-Inflammatories and Antioxidants
  • PARKINSON'S DISEASE
  • STROKE
  • MAJOR DEPRESSIVE DISORDER
  • ACKNOWLEDGMENTS
  • REFERENCES
  • 12 - Nanotechnology-Based Approach for Enhanced Bioavailability and Stability of Tea Polyphenols-A Review
  • INTRODUCTION
  • BIOSYNTHESIS OF CATECHINS
  • HEALTH BENEFITS OF TEA
  • LIMITATIONS OF TEA POLYPHENOLS
  • STRATEGY TO OVERCOME THE?LIMITATIONS
  • NANOENCAPSULATION OF GREEN?TEA POLYPHENOLS
  • CONCLUSION
  • ACKNOWLEDGMENTS
  • REFERENCES
  • Subject Index
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • Z
  • Back Cover

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