Frontiers in Clinical Drug Research - Anti-Allergy Agents: Volume 3

 
 
Frontiers in Clinical Drug Research - Anti-Allergy Agents (Verlag)
  • 1. Auflage
  • |
  • erschienen am 11. Juli 2018
  • |
  • 268 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
978-1-68108-337-7 (ISBN)
 

Frontiers in Clinical Drug Research - Anti-Allergy Agents is a book series comprising of a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews incl

  • Englisch
  • Sharjah
  • |
  • Vereinigte Arabische Emirate
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  • 4,83 MB
978-1-68108-337-7 (9781681083377)
weitere Ausgaben werden ermittelt
  • Intro
  • CONTENTS
  • PREFACE
  • List of Contributors
  • Developing the Perfect Antihistamine for Use in Allergic Conditions: A Voyage in H1 Selectivity
  • Diana R. Cundell* and Kathryn E. Mickle
  • INTRODUCTION
  • Pharmacology of Histamine
  • Cellular Sources of Histamine and Mechanisms of Release
  • Mast Cells and the Inflammatory Environment
  • Histamine and Body Tissues
  • Antihistamines for the Treatment of Allergies
  • Nasal Anatomy and Physiology, Allergic Rhinitis, Allergens and Histamine
  • Allergens and Allergic Rhinitis
  • The Eye Conjunctiva
  • Anatomy And Physiology, Allergic Conjunctivitis and Histamine
  • Allergens and Allergic Conjunctivitis
  • The Skin
  • Anatomy and Physiology, Urticaria and Histamine
  • Allergens and Urticaria
  • Histamine and the H1 Receptor
  • First Generation H1 Antihistamines
  • A History of First Generation Antihistamine Development
  • Ethylenediamines and Ethanolamines
  • Piperazines and Piperidines
  • Phenothiazines and Doxepin
  • A New Genre of Antihistamines With Powerful Central Nervous System Effects
  • Side Effects of The First Generation H1 Antihistamines and Toxicity
  • Central Nervous System H1 Side Effects
  • Adverse Effects of First Generation H1 Antihistamines Due to Lack of Selectivity
  • Toxicity of First Generation Antihistamines
  • Second Generation H1 Antihistamines
  • Safer with Less Side Effects
  • Second Generation Antihistamines With Significant Side Effects: Astemizole, Azelastine and Terfenadine
  • Second Generation Histamines That are First Generation Analogs
  • Acrivastine, Cetirizine and Levocetirizine
  • Cetirizine
  • Levocetirizine
  • Second Generation Piperidine Successes
  • Levocabastine, Loratadine, Desloratadine, Fexofenadine, and Olopatadine
  • Loratadine
  • Desloratadine
  • Fexofenadine
  • Olopatadine
  • Clinical Trial Meta-Analysis Data for Extensively Used Second Generation Antihistamines
  • CONCLUSION AND FURTHER DIRECTIONS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Therapeutics in Chronic Spontaneous Urticaria
  • Alexei Gonzalez-Estrada* and James Fernandez
  • INTRODUCTION
  • TREATMENT
  • ANTIHISTAMINES
  • H1-Antihistamines
  • FIRST-GENERATION H1-ANTIHISTAMINES
  • Hydroxyzine
  • Doxepin
  • SECOND-GENERATION H1-ANTIHISTAMINES
  • Cetirizine
  • Desloratadine
  • Loratadine
  • Fexofenadine
  • Levocetirizine
  • Rupatadine
  • H2-Antihistamines
  • Cimetidine
  • Ranitidine
  • Famotidine
  • Leukotriene Antagonist
  • Montelukast
  • Zafirlukast
  • IMMUNOSUPPRESSIVE MEDICATIONS FOR CSU
  • Hydroxychloroquine
  • Colchicine
  • Dapsone
  • Sulfasalazine
  • Methotrexate
  • Cyclosporine
  • IMMUNOMODULATORY AGENTS
  • Omalizumab
  • Intravenous Immunoglobulin
  • Corticosteroids
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Research and Development for Anti-Asthmatic Agents with a Focus on Phenotype Changing by Ca2+ Signaling in Airway Smooth Muscle Cells
  • Hiroaki Kume1,2,*
  • INTRODUCTION
  • MECHANISM OF AIRWAY SMOOTH MUSCLE TONE
  • AIRWAY SMOOTH MUSCLE TONE REGULATED BY KCA CHANNELS
  • Characteristics and physiological roles of KCa channels
  • Structure of KCa Channels
  • Electrical Characteristics of KCa Channels
  • Physiological Role of KCa Channels
  • Stimulatory Regulation of KCa Channels by ß2-Adrenoceptor Agonists
  • cAMP-Dependent Phosphorylation
  • Membrane-Delimited Activation by Gs
  • Dual Regulation by cAMP-Dependent and -Independent Processes
  • Role in Relaxation by ß2-Adrenoceptor Agonists
  • Inhibitory Regulation of KCa Channels by Muscarinic Receptor Agonists
  • Membrane-Delimited Inhibition by Gi
  • Dual Regulation by Gs and Gi
  • Role in Contraction by Muscarinic Receptor Agonists
  • Regulation of KCa Channels by other Factors (cGMP, Protein Kinase C)
  • AIRWAY SMOOTH MUSCLE TONE REGULATED BY CA2+ DYNAMICS
  • Membrane Potential-Independent Ca2+ Dynamics
  • Membrane Potential-dependent Ca2+ Dynamics
  • Effects of Ca2+ Release from the SR
  • AIRWAY SMOOTH MUSCLE TONE REGULATED BY CA2+ SENSITIZATION
  • Characteristics and Physiological Role of RhoA / Rho-kinase
  • Role of RhoA / Rho-kinase on Contraction
  • Role on ß2-Adrenergic Relaxation
  • INTRINSIC EFFICACY OF ?2-ADRENOCEPTOR AGONISTS
  • Characteristics and Measurement
  • Values of ß2-Adrenergic Intrinsic Efficacy for Airway Smooth Muscle Relaxation
  • Effects of Intrinsic Efficacy on ß2-Adrenegic Desensitization
  • Role of Allosteric GPCR Modulation in Intrinsic Efficacy
  • ROLE OF CA2+ SIGNALING IN AIRWAY DISORDERS
  • Airflow Limitation (Bronchoconstriction)
  • Airway Hyperresponsiveness
  • Desensitization of ß2- Adrenoceptors
  • Ca2+ Dynamics
  • Ca2+ Sensitization
  • Airway Remodeling
  • Cell Proliferation
  • Cell Migration
  • Interaction between Airway Smooth Muscle and Inflammatory Cells
  • PHENOTYPE PLASTICITY
  • Contractile phenotype
  • Synthetic and Proliferative Phenotypes
  • Hyper-Contractile Phenotype
  • Ca2+ Handling
  • Regulation of Phenotype Switching
  • Modulation of Cell Phenotype by Cell Culture
  • RATIONALE USE OF ?2-ADRENOCEPTOR AGONISTS BASED ON THEIR INTRINSIC EFFICACY
  • SYNERGISTIC EFFECTS BETWEEN MUSCARINIC AND ?2-ADRENERGIC RECEPTORS
  • Role of G proteins / KCa Channels Linkage
  • Role of Allosteric GPCR Modulation in Synergistic Effects
  • POSSIBLE EFFECTS OF BRONCHODILATORS ON AIRWAY INFLAMMATION
  • CONCLUSIONS
  • ABBREVIATION
  • CONSENT FOR PUBLICATION
  • ACKNOWLEDGEMENT
  • CONFLICT OF INTEREST STATEMENT
  • REFERENCES
  • Effects of Allergic Rhinitis on Communication Skills
  • Can Cemal Cingi1,*, Erkan Yüksel2 and Nuray Bayar Muluk3
  • 1. INTRODUCTION
  • 2. EFFECTS OF ALLERGIC RHINITIS ON HUMAN RELATIONS
  • 2.1. Psychological Effects
  • 2.2. Physiological Effects
  • 2.3. Behavioral Effects
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Endosomal Toll-like Receptors: Rheostats of Inflammation and Diseases
  • Chhedi Lal Gupta, Rohit Kumar Tiwari, Neelam Pathak and Preeti Bajpai*
  • AN OVERVIEW
  • Toll-like Receptors
  • Structure of Toll-like Receptors
  • Toll-like Receptor Signaling
  • ENDOSOMAL TOLL-LIKE RECEPTORS
  • Ligand Detection by Endosomal TLRs
  • dsRNA Detection by TLR3
  • ssRNA Detection by TLR7 and TLR8
  • CpG DNA Detection by TLR9
  • Endosomal TLRs in Disease Aggravation
  • Role of Endosomal TLRs in Inflammatory and Autoimmune Diseases
  • Role of Endosomal TLRs in Cancer
  • Therapeutic Targeting of Endosomal TLRs
  • Agonists of Endosomal TLRs
  • Antagonists of Endosomal TLRs
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENT
  • REFERENCES
  • SUBJECT INDEX

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