Frontiers in Anti-Infective Drug Discovery: Volume 7

 
 
Frontiers in Anti-Infective Drug Discovery (Verlag)
  • 1. Auflage
  • |
  • erschienen am 31. Mai 2018
  • |
  • 295 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
978-1-68108-562-3 (ISBN)
 

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal ch

  • Englisch
  • Sharjah
  • |
  • Vereinigte Arabische Emirate
PublishDrive
  • 3,63 MB
978-1-68108-562-3 (9781681085623)
weitere Ausgaben werden ermittelt
  • Intro
  • CONTENTS
  • PREFACE
  • List of Contributors
  • The Role of the Microbiota in the Genesis of Gastrointestinal Cancers
  • Edda Russo and Amedeo Amedei*
  • 1. INTRODUCTION
  • 2. THE HUMAN MICROBIOTA
  • 3. THE GASTROINTESTINAL MICROBIOTA
  • 3.1. Composition and Activities
  • 3.2. Gastro-Intestinal Colonization by the Microbiota and Selection
  • 3.3. The Human Microbiome Project
  • 3.4. Gut Enterotypes
  • 4. THE ROLE OF MICROBIOTA IN TUMOR DEVELOPMENT
  • 4.1. Proposed Models for Microbiota-induced Carcinogenesis
  • 4.2. Antibacteria-Specific Immune Response and Cancer Promotion
  • 5. MICROBIOTA AND GI CANCERS
  • 5.1. Gut Bacteria Dysbiosis Associated with GI Cancer
  • 5.2. Microbiota Involvement in Gastric and Esophageal Cancers, the Role of Helicobacter pylori
  • 5.3. Microbiota Involvement in Colorectal Cancer
  • 5.3.1. Specific Gut Bacteria and CRC
  • 5.3.2. Bacteria Metabolites and CRC
  • 5.4. Gallbladder Cancer
  • 5.5. Liver Cancer
  • 5.6. Pancreatic Cancer
  • 6. BENEFICIAL ACTIVITIES OF GUT MICROBIOTA
  • 6.1. Antitumorigenic Impact of Microbiota
  • 6.2. Manipulating the Microbiota for Cancer Therapy
  • 7. CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Towards Host Cell-Targeting Therapies to Treat Dengue Virus Infections
  • Cybele C. García1,2, Verónica M. Quintana1, Viviana Castilla1 and Elsa B. Damonte1,2,*
  • INTRODUCTION
  • INTERACTION WITH CELL RECEPTORS
  • ENDOCYTOSIS AND FUSION FOR UNCOATING
  • LIPID METABOLISM
  • PROTEIN TRANSLATION
  • UNFOLDED PROTEIN RESPONSE
  • UBIQUITIN PROTEASOME PATHWAY
  • NUCLEOTIDE METABOLISM
  • KINASES
  • Mitogen-activated Protein Kinases
  • ERK Pathway
  • JNK Pathway
  • p38 Pathway
  • Other Kinases
  • Src, Ab1 and Fyn Kinases
  • AP2-associated Protein Kinase 1 and Cyclin G-associated Kinase
  • Phosphatidylinositol 3 Kinase/Akt Pathway
  • PROTEIN PROCESSING
  • Endoplasmic Reticulum a-glucosidases
  • Furin
  • Endoplasmic Reticulum Associated Signal Peptidase
  • INNATE ANTIVIRAL RESPONSE
  • Interferon Activity
  • Cell-intrinsic Restriction Factors
  • CONCLUDING REMARKS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Synergistic Interaction Between Plant Products and Antibiotics Against Potential Pathogenic Bacteria
  • Banasri Hazra1,*, Sutapa Biswas Majee2, Subhalakshmi Ghosh1 and Dhruti Avlani2
  • INTRODUCTION
  • BACTERIAL RESISTANCE TOWARDS CLINICAL ANTIBIOTICS
  • Background
  • Mechanisms and Associated Factors
  • SCREENING STRATEGIES TO CHARACTERISE PLANT PRODUCTS WITH POTENTIAL RESISTANCE MODIFYING ACTIVITY
  • ASSESSMENT OF SYNERGISTIC INTERACTION BETWEEN ANTIBIOTIC AND A PHYTOCOMPOUND AGAINST RESISTANT BACTERIA
  • Fractional Inhibitory Concentration Index (FICI)
  • Modulation Factor (MF)
  • Isobologram
  • SEARCH FOR PLANT-DERIVED SECONDARY METABOLITES WITH PROSPECTIVE RESISTANCE MODIFYING ACTIVITY
  • Key Early Studies Pertaining to Discovery of RMAs from Plants
  • Recent Studies
  • PHYTOCHEMICALS AND RELEVANT BACTERIAL RESISTANCE MECHANISMS
  • Efflux Pump Inhibition
  • Alteration of Bacterial Cell Membrane Permeability
  • Protein Synthesis Inhibition
  • Enzymatic Inhibition
  • Biofilm Formation Inhibition
  • ADDITIONAL STRATEGIES FOR SCREENING AND DEVELOPMENT OF PLANT PRODUCTS AS ADJUVANTS IN ANTIMICROBIAL THERAPY
  • In Vivo Validation
  • Standardisation of Botanical Extracts
  • iChip Technology
  • CONCLUDING REMARKS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • ABBREVIATIONS
  • REFERENCES
  • Molecular Modelling Approaches to Antibacterial Drug Design and Discovery
  • Agnieszka A. Kaczor1,2,*, Prasanthi Medarametla2, Damian Bartuzi1, Magdalena Kondej1, Dariusz Matosiuk1 and Antti Poso2
  • INTRODUCTION
  • CHALLENGES IN DESIGN AND DISCOVERY OF ANTIBACTERIAL DRUGS
  • DRUG TARGETS FOR ANTIBIOTICS
  • MOLECULAR MODELLING TECHNIQUES FOR DESIGN AND DISCOVERY OF ANTIBACTERIAL DRUGS
  • Protein 3D Structure Prediction
  • Comparative/Homology Modelling
  • Fold Recognition/Threading
  • Ab initio Modelling
  • Protein Structure Prediction in Anti-Bacterial Drug Design
  • Molecular Docking
  • Molecular Docking as an Approach to Study Ligand-Protein Interactions
  • Application of Molecular Docking in Anti-Bacterial Drug Discovery
  • Molecular Dynamics
  • Molecular Dynamics as an Approach to Study Dynamic Aspects of Ligand-Protein Interactions
  • Application of Molecular Dynamics for Antibacterial Drug Discovery
  • QSAR
  • QSAR as a Method Applied in Drug Design
  • Application of QSAR for Antibacterial Drug Discovery
  • Pharmacophore Models
  • Importance of Pharmacophore Models in Drug Design
  • Application of Pharmacophore Models for Antibacterial Drug Discovery
  • Virtual Screening
  • Virtual Screening as a Method of Searching Large Databases
  • Application of Virtual Screening for Antibacterial Drug Discovery
  • Prediction of Drug-Likeness and ADMET Properties
  • SUMMARY AND PERSPECTIVE
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Nucleic Acid Aptamers Against Virulence Factors of Drug Resistant Pathogens
  • Canan Ozyurt, Ozge Ugurlu, Burhan Bora and Serap Evran*
  • INTRODUCTION
  • Selection of Aptamers
  • Aptamers Against Toxins and Protein Virulence Factors
  • Aptamers Against Staphylococcal Toxins
  • Aptamers Against Clostridium Toxins
  • Aptamers Against E. coli Toxins
  • Aptamers Against Aspergillus and Penicillium Toxins
  • Aptamers Against Mycobacterium Tuberculosis Toxins
  • Aptamers Against Other Toxins
  • Aptamers Against Quorum Sensing Molecules
  • Modifications of Aptamers for Improving Therapeutic Potential
  • 2'-F-Modified RNA Aptamers
  • 2'-NH2 Modification of Aptamers
  • Other Ribose Modified Aptamers
  • Phosphorothioate Modification
  • Nucleobase Modification of Aptamers
  • CONCLUDING REMARKS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENT
  • REFERENCES
  • Overcoming Fungal Multidrug Resistance by Natural Compounds Targeting Efflux Pumps
  • Shweta Singh, Sandeep Hans, Zeeshan Fatima* and Saif Hameed*
  • INTRODUCTION
  • CANDIDA EFFLUX PUMPS
  • ABCS TRANSPORTER FAMILY
  • MFS TRANSPORTER FAMILY
  • NATURAL EPI TARGETING ABC TRANSPORTERS
  • NATURAL EPI TARGETING MFS TRANSPORTERS
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • The Infections and Hydrogen Sulfide
  • Ravinder R. Gaddam, Piyush Jha and Madhav Bhatia*
  • INTRODUCTION
  • H2S AND VIRAL INFECTIONS
  • H2S AND BACTERIAL INFECTIONS
  • H2S AND MYCOPLASMA INFECTION
  • H2S AND SEPSIS
  • H2S AND ANTIBACTERIAL RESISTANCE
  • H2S AND FUNGAL INFECTIONS
  • H2S AND PROTOZOAL INFECTION - MALARIA
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Subject Index

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