Multiple Sclerosis (MS) is one of the main causes of disability in young adult population. The estimated burden of the disease worldwide is about three million people. The pathogenic mechanism of MS involves both auto immune and degenerative processes. These two mechanisms are thought to determine a combination of events leading to several clinical pattern of disease onset and course.
Multiple Sclerosis: Bench to Bedside provides the most up-to-date and concise reviews on the critical issues of multiple sclerosis from around the world. This book is written by leaders and experts in the field of multiple sclerosis research and is divided into easy to read sections. Section I focuses on basic science aspects of Multiple Sclerosis, including potential biomarkers, molecular biology, heat shock proteins, oxidative stress, genetic and epigenetics. Section II focuses on clinical and epidemiological aspects of Multiple Sclerosis, including remyelination therapy, neuroplasticity-based technologies and interventions. This is an important reference book and a must-read for Postgraduate Medical Scholars, Basic Science Researchers and Neurologists in Clinical Practice.
Section I: Basic Science Aspects of Multiple Sclerosis
1 Extracellular Vesicles in Multiple Sclerosis as Possible Biomarkers: Dream or Reality?
Maria Magdalena Barreca, Emanuele Aliotta and Fabiana Geracii
2 Manipulation of Oxygen and Endoplasmic Reticulum Stress Factors as Possible Interventions for Treatment of Multiple Sclerosis: Evidence For and Against
Paul Eggleton, Gary R. Smerdon, Janet Holley and Nick Gutowski
3 Heat Shock Proteins in Multiple Sclerosis
Ortan Pinar, Yildirim Akan Ozden, Erkizan Omur and Gedizlioglu Muhtesem
4 Meaning of Self in Multiple Sclerosis: Implications for Treatment and Rehabilitation
Maciej Wilski and Tomasz Tasiemski
5 Multiple Sclerosis and EIF2B5: A Paradox or a Missing Link
Insha Zahoor, Ehtishamul Haq and Ravouf Asimi
6 Molecular Genetic and Epigenetic Basis of Multiple Sclerosis
7 Role of Olygodendrocyte Dysfunction in Demyelination, Remyelination and Neurodegeneration in Multiple Sclerosis
Adriana Octaviana Dulamea
Section II: Clinical and Epidemiological Aspects of Multiple Sclerosis
8 Clinical Neurophysiology of Multiple Sclerosis
Mario Habek, Ivan Adamec, Barbara Barun, Luka Crnosija, Tereza Gabelic and Magdalena Krbot Skoric
9 Multiple Sclerosis Epidemiology in Europe
Daiana Bezzini and Mario A. Battaglia
10 Timing of Future Remyelination Therapies and Their Potential to Stop Multiple Sclerosis Progression Burcu Zeydan, Moses Rodriguez and Orhun Kantarci
11 Neuroplasticity-Based Technologies and Interventions for Restoring Motor Function in Multiple Sclerosis
Sofia Straudi and Nino Basaglia