Liver Regeneration

Basic Mechanisms, Relevant Models and Clinical Applications
 
 
Academic Press Inc
  • 1. Auflage
  • |
  • erschienen am 21. August 2015
  • |
  • 326 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
E-Book | PDF mit Adobe DRM | Systemvoraussetzungen
978-0-12-800431-9 (ISBN)
 
Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease.

By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management.

Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration.



- Summarizes current liver regeneration studies and discussions on expected discoveries
- Provides an overview of standard scientific and cutting-edge technologies to study liver regeneration
- Presents details on the molecular mechanisms that affect liver regeneration
- Highly illustrated, with hundreds of full-color, graphic photographs and illustrations to enhance the learning process
  • Englisch
  • USA
Elsevier Science & Technology (Digital)
  • Für höhere Schule und Studium
  • |
  • Researchers in the area of liver biology

Approx. 300 illustrations (300 in full color)
  • Höhe: 235 mm
  • |
  • Breite: 191 mm
  • 19,78 MB
978-0-12-800431-9 (9780128004319)
0128004312 (0128004312)
weitere Ausgaben werden ermittelt
Chapter 1. Introduction to Liver Regeneration: History and General Principles
Chapter 2. Models to Study Liver Regeneration
Chapter 3. Alternative Models to Study Liver Regeneration: Zebrafish
Chapter 4. The Priming and Progression Theory of Liver Regeneration
Chapter 5. Primary and Secondary Mitogen Theory of Liver Regeneration
Chapter 6. Developmental Pathways in Liver Regeneration
Chapter 7. Mechanisms of Termination of Liver Regeneration
Chapter 8. Modulation of Extracellular Matrix During Liver Regeneration
Chapter 9. Role of Chemokines
Chapter 10. Role of Nuclear Receptors
Chapter 11. Role of Developmental Morphogens in Liver Regeneration
Chapter 12. Regulation of Cell Cycle during Liver Regeneration
Chapter 13. Role of microRNAs and Long Non-Coding RNAs in Liver Regeneration
Chapter 14. Changes in Hepatocyte Ploidy during Liver Regeneration
Chapter 15. Role of Endothelial Cells in Liver Regeneration
Chapter 16. Use of Computational Biology, Omics Technologies to Understand Liver Regeneration
Chapter 17. Mitogen Induced Cell Proliferation in the Liver
Chapter 18. Effect of Nutritional Diversity on Liver Regeneration
Chapter 19. Introduction of Hepatic Progenitor Cells
Chapter 20. Cellular Transdifferentiation in the Liver
Chapter 21. Activation of Hepatic Progenitor Cells in Liver Regeneration After Chemical Injury to the Liver
Chapter 22. Hepatic Progenitor Cells and iPS Cells as a Source of Mature Hepatocytes
Chapter 23. Progenitor Cell Transplantation: Experimental Models
Chapter 24. Liver Regeneration as a Therapy for Acute Liver Failure
Chapter 25. Liver Regeneration Following Liver Transplantation
Chapter 26. Hepatocyte Transplantation Therapy
Chapter 27. Liver Regeneration: The Biliary Perspective

Contributors


Gianfranco Alpini

Department of Internal Medicine, College of Medicine, Texas A&M University Health Science Center

Division of Research, Central Texas Veterans Health Care System, and BaylorScott & White Digestive Disease Research Center, BaylorScott & White, Temple, Texas, USA

Udayan Apte     Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA

Vishakha Bhave     Philadelphia College of Osteopathic Medicine, School of Pharmacy, Suwanee, Georgia, USA

Alicia R. Brown     Pediatric Stem Cell Research and Hepatic Disorders, Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

Jean S. Campbell     Northwest Liver Research Program, and Department of Pathology, University of Washington, Seattle, Washington, USA

Daniel Cook     Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, and Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA

Anna Mae Diehl     Division of Gastroenterology, Duke University, Durham, North Carolina, USA

Lili Ding     Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA, and Shanghai Key Laboratory of Complex Prescriptions and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Andrew W. Duncan     Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Mingjie Fan     Institute of Life Science, Taishan Medical University, Taian, China

Christopher M. Freeman     Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA

Shannon Glaser

Department of Internal Medicine, College of Medicine, Texas A&M University Health Science Center

Division of Research, Central Texas Veterans Health Care System

BaylorScott & White Digestive Disease Research Center, BaylorScott & White, Temple, Texas, USA

Wolfram Goessling     Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, and Harvard Stem Cell Institute and Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

Yuyan Han     Department of Internal Medicine, College of Medicine, Texas A&M University Health Science Center, Temple, Texas, USA

Jiansheng Huang     Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA

Wendong Huang     Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA

Alex B. Lentsch     Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA

Yanfeng Li     Department of Medicine, Division of Gastroenterology and Hepatology, and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA

Pallavi B. Limaye     Xenometrics LLC, Stilwell, Kansas, USA

Joseph Locker     Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Mariana Verdelho Machado     Division of Gastroenterology, Duke University, Durham, North Carolina, USA

Luca Maroni     Clinic of Gastroenterology, Università Politecnica delle Marche, "Ospedali Riuniti" University Hospital, Ancona, Italy

Marco Marzioni     Clinic of Gastroenterology, Università Politecnica delle Marche, "Ospedali Riuniti" University Hospital, Ancona, Italy

Fanyin Meng     Division of Research, Central Texas Veterans Health Care System, Temple, and BaylorScott & White Digestive Disease Research Center, BaylorScott & White, Texas, USA

George K. Michalopoulos     Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Satdarshan Pal Singh Monga     Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

Kari Nichole Nejak-Bowen     Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA

Yulia A. Nevzorova     Department of Medicine III, University Hospital, Aachen, Germany

Hiroyuki Nojima     Department of Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA

Bryon E. Petersen     Pediatric Stem Cell Research and Hepatic Disorders, Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

Liya Pi     Pediatric Stem Cell Research and Hepatic Disorders, Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

Zsuzsanna Polgar     Department of Medicine, Division of Gastroenterology and Hepatology, and Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA

Michele T. Pritchard     Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA

Debolina Ray     Department of Internal Medicine, College of Medicine, Texas A&M University Health Science Center, Temple, Texas USA

Kimberly J. Riehle     Northwest Liver Research Program; Department of Surgery, and Department of Pathology, University of Washington, Seattle, Washington, USA

Kevin Riggle     Department of Surgery, University of Washington, Seattle, Washington, USA

Paulette M. Robinson     Pediatric Stem Cell Research and Hepatic Disorders, Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

Jayanta Roy-Chowdhury

Department of Medicine, Division of Gastroenterology and Hepatology

Marion Bessin Liver Research Center, and Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA

Namita Roy-Chowdhury     Department of Medicine, Division of Gastroenterology and Hepatology; Marion Bessin Liver Research Center, and Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA

David A. Rudnick     Department of Pediatrics, and Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, USA

David A. Shafritz     Marion Bessin Liver Research Center, Division of Gastroenterology and Liver Diseases, Albert Einstein College of Medicine, Bronx, NY, USA

David C. Sullivan     Pediatric Stem Cell Research and Hepatic Disorders, Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

Christian Trautwein     Department of Medicine III, University Hospital, Aachen, Germany

Rajanikanth Vadigepalli     Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia,...

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