Natural Products Targeting Clinically Relevant Enzymes

 
 
Wiley-VCH (Verlag)
  • erschienen am 29. August 2017
  • |
  • XVIII, 330 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
978-3-527-80593-8 (ISBN)
 
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more.
By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
1. Auflage
  • Englisch
  • Newark
  • |
  • Deutschland
  • 8,39 MB
978-3-527-80593-8 (9783527805938)
3527805931 (3527805931)
weitere Ausgaben werden ermittelt
PAULA B. ANDRADE is Associate Professor at the Faculty of Pharmacy of the University of Porto. As head of the Pharmacognosy lab, she also coordinates the natural products group of the REQUIMTE/LAQV, an institute active in Green Chemistry, and evaluates research projects for various international entities. Her research on bioactive substances originating from matrices of marine and terrestrial origin was published in more than 30 book chapters and more than 300 articles in international journals.

PATRICIA VALENTÃO obtained her PhD in Pharmaceutical Sciences at the University of Porto for work on pharmacognosy. She was appointed Assistant Professor at the Faculty of Pharmacy, University of Porto in 2007. Her research focuses on qualitative and quantitative metabolite profiling of terrestrial and marine natural matrices with the goal to reveal composition/activity relationships of these compounds in various clinically-relevant areas. Patricia Valentão is member of the REQUIMTE/LAQV Institute of Green Chemistry and editorial board member of the "EJournal of Chemistry". She (co)authored more than 30 book chapters and more than 250 articles in international journals.

DAVID M. PEREIRA obtained his PhD in Pharmaceutical Sciences at the University of Porto for work on phytochemistry and pharmacognosy. In 2014 he was appointed Assistant Professor at the Faculty of Pharmacy of the same university. David Pereira edited one book, contributed more than 20 book chapters and over 60 papers covering research areas of natural products, inflammation, drug discovery and analytical techniques. He also serves in the Editorial Board of several journals related to natural products and analytical techniques. He is appointed expert in the "Global Burden of Disease" program of the University of Washington, and reviewer/consultant in Biomedical Sciences for several European institutions.
Natural products as enzyme inhibitors
Natural ACE inhibitors with antihypertensive properties
Hypoglycaemic effects of plants food constituents via inhibition of carbohydrate-hydrolysing enzymes: from chemistry to future applications.
Natural Product Inhibitors of Cyclooxygenase (COX) Enzymes: Current Status and Future Perspective
Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid Biosynthesis implicated in inflammation and cancer
Natural inhibitors of mitochondrial respiratory chain: therapeutic and toxicological implications
Angiotensin-I-Converting enzyme (ACE-I) inhibitors from marine bio-resources
Refreshing the Marine-derived Chemotherapeutic Pipeline
Recent developments on the natural products and their derivatives targeting PfDHFR (Dihydrofolate reductase) and PfHSP (Heat sensitive protein)
Phospholipase A2 inhibitors of marine origin: a target for inflammation
Natural Plant-derived Acetylcholinesterase Inhibitors: Relevance for Alzheimer's disease
Molecular Targets of Clinically-Relevant Natural Products from Filamentous Marine Cyanobacteria
Natural inhibitors of beta-secretase
Anti-HIV natural products

List of Contributors


  1. Catarina Andrade
  2. REQUIMTE/LAQV Universidade do Porto
  3. Laboratório de Farmacognosia Departamento de Química Faculdade de Farmácia
  4. Rua de Jorge Viterbo Ferreira, Nº 228,
  5. 4050-213 Porto
  6. Portugal

 

  1. Paula B. Andrade
  2. REQUIMTE/LAQV
  3. Universidade do Porto
  4. Laboratório de Farmacognosia Departamento de Química Faculdade de Farmácia
  5. Rua de Jorge Viterbo Ferreira, Nº 228,
  6. 4050-213 Porto
  7. Portugal

 

  1. Anna Arola-Arnal
  2. Universitat Rovira i Virgili
  3. Biochemistry and Biotechnology Department
  4. Marcel lí Domingo s/n
  5. 43007 Tarragona
  6. Spain

 

  1. Vasundhra Bhandari
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Anupam Bishayee
  2. Larkin University
  3. Department of Pharmaceutical Sciences
  4. College of Pharmacy
  5. Miami, FL 33169
  6. USA

 

  1. Marco Bonesi
  2. University of Calabria
  3. Department of Pharmacy
  4. Health and Nutritional Sciences
  5. Rende (CS)
  6. Italy

 

  1. Nady Braidy
  2. UNSW Medicine
  3. School of Psychiatry, NPI
  4. Barker Street
  5. Randwick
  6. NSW 2031
  7. Australia

 

  1. Francisca I. Bravo
  2. Universitat Rovira i Virgili
  3. Biochemistry and Biotechnology Department
  4. Marcel lí Domingo s/n
  5. 43007 Tarragona
  6. Spain

 

  1. Helen Chan
  2. Genning Partners Company Limited
  3. Causeway Bay; Institute of Medical Research Central; and Vita Green
  4. Pharmaceutical (Hong Kong), Ltd. Tai Po, N.T.
  5. Hong Kong
  6. China

 

  1. Chi Fai Cheung
  2. The Chinese University of Hong Kong
  3. School of Biomedical Sciences
  4. Faculty of Medicine Shatin, N.T.,
  5. Hong Kong
  6. China

 

  1. Ramesh Dasari
  2. Texas State University
  3. Department of Chemistry and Biochemistry
  4. San Marcos TX 78666
  5. USA

 

  1. Shobha Ediga
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Wei-Shuo Fang
  2. Institute of Materia Medica
  3. Chinese Academy of Medical Science
  4. Beijing 100050
  5. China
  1. Priyanka Voori Giri
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Nelson G. M. Gomes
  2. REQUIMTE/LAQV
  3. University of Porto
  4. Laboratory of Pharmacognosy
  5. Department of Chemistry
  6. Faculty of Pharmacy
  7. R. Jorge Viterbo Ferreira Nº.
  8. 2284050-313 Porto
  9. Portugal

 

  1. Na Guo
  2. Institute of Materia Medica
  3. Chinese Academy of Medical Science
  4. Beijing 100050
  5. China

 

  1. Tharusha Jayasena
  2. UNSW Medicine
  3. School of Psychiatry, NPI
  4. Barker Street
  5. Randwick NSW 2031
  6. Australia

 

  1. Robert Kiss
  2. Université Libre de Bruxelles
  3. Campus de la Plaine
  4. Laboratoire de Cancérologie et de Toxicologie
  5. Expérimentale
  6. Faculté de Pharmacie
  7. CP205/1, Boulevard du Triomphe
  8. 1050 Brussels
  9. Belgium

 

  1. Alexander Kornienko
  2. Texas State University
  3. Department of Chemistry and Biochemistry
  4. San Marcos TX 78666
  5. USA

 

  1. Naresh Kumar
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Vipan Kumar
  2. Guru Nanak Dev University
  3. Department of Chemistry
  4. Grand Trunk Road
  5. Amritsar 143005
  6. India

 

  1. Florence Lefranc
  2. Université Libre de Bruxelles
  3. Service de Neurochirurgie
  4. Hôpital Erasme
  5. 808 Route de Lennik
  6. 1070 Brussels
  7. Belgium

 

  1. Monica R. Loizzo
  2. University of Calabria
  3. Department of Pharmacy Health and Nutritional Sciences Rende (CS)
  4. Italy

 

  1. Maria Margalef
  2. Universitat Rovira i Virgili
  3. Biochemistry and Biotechnology Department
  4. Marcel lí Domingo s/n
  5. 43007 Tarragona
  6. Spain

 

  1. Begoña Muguerza
  2. Universitat Rovira i Virgili
  3. Biochemistry and Biotechnology Department
  4. Marcel lí Domingo s/n
  5. 43007 Tarragona
  6. Spain

 

  1. Seyed M. Nabavi
  2. Baqiyatallah University of Medical Sciences
  3. Applied Biotechnology Research Center
  4. Tehran
  5. Iran

 

  1. Charlene Cheuk Wing Ng
  2. GKT School of Medicinal Education
  3. King's College London SEI IUL
  4. United Kingdom

 

  1. Tzi Bun Ng
  2. The Chinese University of Hong Kong
  3. School of Biomedical Sciences
  4. Faculty of Medicine Shatin, N.T.,
  5. Hong Kong
  6. China

 

  1. Nuria de Pedro
  2. Life Length
  3. Parque Científico de Madrid
  4. Faraday 7
  5. Campus de Cantoblanco
  6. 28049 Madrid Spain

 

  1. Fernando Peláez
  2. CNIO - Spanish National Cancer Research Centre Biotechnology Programme
  3. C/Melchor Fernández Almagro, 3
  4. 28029 Madrid
  5. Spain

 

  1. David M. Pereira
  2. REQUIMTE/LAQV
  3. Universidade do Porto
  4. Laboratório de Farmacognosia Departamento de Química Faculdade de Farmácia
  5. Rua de Jorge Viterbo Ferreira, Nº 228, 4050-213 Porto
  6. Portugal

 

  1. Renato B. Pereira
  2. REQUIMTE/LAQV
  3. University of Porto
  4. Laboratory of Pharmacognosy
  5. Department of Chemistry
  6. Faculty of Pharmacy
  7. R. Jorge Viterbo Ferreira Nº. 228
  8. 4050-313 Porto
  9. Portugal

 

  1. Anne Poljak
  2. UNSW Medicine
  3. School of Psychiatry, NPI
  4. Barker Street
  5. Randwick NSW 2031
  6. Australia

 

  1. Raghu Raj
  2. Guru Nanak Dev University
  3. Department of Chemistry
  4. Grand Trunk Road
  5. Amritsar 143005
  6. India

 

  1. Chintalapally V. Rao
  2. University of Oklahoma
  3. Center for Cancer Prevention
  4. and Drug Development
  5. Health Sciences Center
  6. Oklahoma city, OKUSA

 

  1. Luca Rastrelli
  2. University of Salerno
  3. Department of Pharmacy
  4. Fisciano (SA)
  5. Italy

 

  1. Pallu Reddanna
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Gorla V. Reddy
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Perminder Sachdev
  2. UNSW Medicine
  3. School of Psychiatry, NPI
  4. Barker Street
  5. Randwick NSW 2031
  6. Australia

 

  1. Tânia Silva
  2. REQUIMTE/LAQV
  3. Universidade do Porto
  4. Laboratório de Farmacognosia Departamento de Química Faculdade de Farmácia
  5. Rua de Jorge Viterbo Ferreira Nº 228 4050-213 Porto
  6. Portugal

 

  1. Sandhya Singh
  2. University of Hyderabad
  3. Department of Animal Biology
  4. School of Life Sciences
  5. Hyderabad
  6. 500046 Telangana
  7. India

 

  1. Eduardo Sobarzo-Sánchez
  2. University of Santiago de Compostela
  3. Laboratory of Pharmaceutical Chemistry
  4. Department of Organic Chemistry Faculty of Pharmacy 15782 Santiago de Compostela
  5. Spain
  6. and
  7. Universidad Central de Chile
  8. Instituto de Investigación e Innovación en Salud
  9. Facultad de Ciencias de la...

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