Novel Developments in Pharmaceutical and Biomedical Analysis

 
 
Recent Advances in Analytical Techniques (Verlag)
  • 1. Auflage
  • |
  • erschienen am 24. April 2018
  • |
  • 360 Seiten
 
E-Book | ePUB mit Adobe DRM | Systemvoraussetzungen
978-1-68108-574-6 (ISBN)
 

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents information about a selection of analytical techniques. Readers will find information about developments in analytical methods su

  • Englisch
  • Sharjah
  • |
  • Vereinigte Arabische Emirate
PublishDrive
  • 4,26 MB
978-1-68108-574-6 (9781681085746)
weitere Ausgaben werden ermittelt
  • Intro
  • CONTENTS
  • PREFACE
  • List of Contributors
  • Advances in Validated Chromatographic Assay of Solid Dosage Forms and Their Drug Dissolution Studies
  • Sevinc Kurbanoglu1, Ozgur Esim2, Ayhan Savaser2, Sibel A. Ozkan1,* and Yalcin Ozkan2
  • INTRODUCTION
  • Classification of Solid Oral Dosage Forms
  • Extracts
  • Powders
  • Granules
  • Pellicles
  • Pills
  • Capsules
  • Lozenges, Troches, Pastilles
  • Oromucosal Preparations
  • Tablets
  • Pellets
  • Quality Control of Solid Oral Dosage Forms
  • Uniformity of Dosage Units
  • Disintegration
  • Dissolution
  • Importance of Dissolution in Pharmacy
  • Comparison of Dissolution Profiles
  • In Vitro and In Vivo Relationships and Bioequivalence Challenges in Dissolution Method Development
  • Liquid Chromatography in Dissolution Testing
  • Validation in Chromatographic Analysis
  • System Suitability Tests
  • Linearity and Range
  • Limit of Detection
  • Limit of Quantification
  • Accuracy
  • Precision
  • Selectivity
  • Sensitivity
  • Robustness
  • Stability
  • Development of Method for Drug Dissolution Testing
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Novel Validated UHPLC Method for the Estimation of Drug Active Compounds
  • Mehmet Gumustas, Bengi Uslu and Sibel A. Ozkan*
  • INTRODUCTION
  • Liquid Chromatographic Techniques
  • Stationary Phases (Columns)
  • UHPLC Over HPLC
  • Detector Types for UHPLC
  • UV-VIS Detectors
  • Tunable UV (TUV) Detector
  • Photo Diode Array (PDA) Detector
  • Fluorescence (FLR) Detector
  • Refractive Index (RI) Detector
  • Evaporative Light Scattering (ELS) Detector
  • Mass Spectrometer (MS) Detector
  • Application on Drug Assay
  • CONCLUDING REMARKS
  • FUTURE DEMANDS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • HILIC Based LC/MS for Metabolite Analysis
  • Emirhan Nemutlu* and Sedef Kır
  • INTRODUCTION
  • Separation Mechanism
  • PARAMETERS EFFECTS ON SEPARATIONS
  • Stationary Phase Effects
  • Mobile Phase Effects on Separation
  • Organic Phase
  • pH
  • Ionic Strength
  • Detectors
  • Sample Preparation
  • Development Steps of HILIC Method
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • In Vitro Methods for the Evaluation of Oxidative Stress
  • Hande Gurer Orhan1,*, Sibel Suzen2, Tamás Bálint Csont3, Miroslav Pohanka4, Bozena Nejman-Falenczyk5, Grzegorz Wegrzyn5 and Luciano Saso6
  • INTRODUCTION
  • 1. DETERMINATION OF LIPID, PROTEIN AND DNA OXIDATION PRODUCTS AS BIOMARKERS OF EXPOSURE TO REACTIVE OXYGEN SPECIES
  • 1.1. Lipid Oxidation Products as Biomarkers
  • Aldehydes
  • Isoprostanes
  • 1.2. Protein Oxidation Products as Biomarkers
  • Protein Carbonyls
  • Oxidized Amino Acids
  • 1.3. DNA Oxidation Products as Biomarkers
  • 2. DETECTION OF FREE RADICALS IN BIOLOGICAL SAMPLES BY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY
  • 3. FLUORESCENT ASSAYS FOR DETECTION OF REACTIVE OXYGEN AND NITROGEN SPECIES IN BIOLOGICAL SYSTEMS
  • 4. VOLTAMMETRY OF LOW MOLECULAR WEIGHT ANTIOXIDANTS.
  • 5. MEASUREMENT OF OXIDATIVE STRESS IN BACTERIA
  • 5.1. Direct and Indirect Probe-based Measurement of ROS
  • 5.2. Measurement of the Oxidative Damage to Biomolecules
  • Measurement of Protein Damage
  • Measurement of Lipid Peroxidation
  • 5.3. Measurement of Antioxidants
  • CONCLUSIONS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • The Application of Vibrational Spectroscopy in Studies of Structural Polymorphism of Drugs
  • Przemyslaw Zalewski1, Gabriela Wiergowska1,2, Joanna Goscianska3, Kornelia Lewandowska4 and Judyta Cielecka-Piontek1,*
  • INTRODUCTION
  • Polymorphism of Active Pharmaceutical Substance
  • The Influence of Polymorphism and Amorphization on the Physicochemical Properties of Active Pharmaceutical Ingredients and Excipients
  • Vibrational Methods Used for Identification of Crystalline and Amorphous Forms of Active Pharmaceutical Ingredients and Excipients
  • Infrared Absorption Spectroscopy
  • Attenuated Total Reflectance Spectroscopy
  • Raman Spectroscopy
  • Polymorphism of Excipients
  • Methods of Stabilization of Polymorphic and Amorphous Forms of Active Pharmaceutical Ingredients
  • CONCLUDING REMARKS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Electrochemical Biosensors Based on Conductive Polymers and Their Applications in Biomedical Analysis
  • Slawomira Skrzypek* and Pawel Krzyczmonik
  • INTRODUCTION
  • CONDUCTIVE POLYMERS
  • NANOSTRUCTURED MATERIALS
  • Quantum Dots
  • Core-type Quantum Dots
  • Core-shell Quantum Dots
  • Alloyed Quantum Dots
  • Carbon Nanostructured Materials
  • Fullerenes and Nanotubes
  • Graphene
  • Functionalization with Nanoparticles
  • Functionalization with Organic Compounds
  • Functionalization with Polymers
  • Functionalization with Biomaterials
  • TYPES OF DETECTION IN BIOSENSORS
  • Potentiometric Detection
  • Amperometric Detection
  • Detection of Oxygen
  • Detection of Hydrogen Dioxide
  • Detection of NADH
  • BIOSENSORS
  • Glucose Biosensors
  • Cholesterol Biosensors
  • Biosensor Based on Laccase
  • Urea Biosensors
  • Affinity Biosensors
  • CONCLUDING REMARKS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • New Trends in Electrochemical Sensors Modified with Carbon Nanotubes and Graphene for Pharmaceutical Analysis
  • Burcin Bozal-Palabiyik, Burcu Dogan-Topal, Sibel A. Ozkan and Bengi Uslu*
  • INTRODUCTION
  • CARBON NANOTUBES
  • The Structure and Properties of CNTs
  • Synthesis and Characterization of CNTs
  • Preparation of CNT-Based Electrodes
  • Advantages and Limitations of CNT-Modified Electrodes
  • Applications of CNTs in Pharmaceutical Analysis
  • GRAPHENE
  • The Structure and Properties of Graphene
  • Synthesis and Characterization of Graphene
  • Preparation of Graphene-Based Electrodes
  • Advantages and Limitations of Graphene-Modified Electrodes
  • Applications of Graphene in Pharmaceutical Analysis
  • CONCLUSION
  • ABBRAVIATIONS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Electrochemical Nanobiosensors in Pharmaceutical Analysis
  • Sevinc Kurbanoglu1,2, Sibel A. Ozkan1 and Arben Merkoçi2,3,*
  • INTRODUCTION
  • (Bio)Receptors
  • Immobilization of the Biological Materials
  • Adsorption
  • Encapsulation
  • Entrapment
  • Covalent Binding
  • Crosslinking
  • Transducer Part of the Biosensors
  • Nanomaterials in Nanobiosensing
  • Applications of Electrochemical Nanobiosensors in Pharmaceutical Analysis
  • a. Antibiotics, Antibacterials and Antimicrobials
  • b. Cardiac Stimulant
  • c. Antineoplastic Agents
  • d. Antiviral Drugs
  • e. Antidepressant and Antipsychotic Drugs
  • f. Antiemetic Drugs
  • g. Adrenergic Agonist
  • h. Antiparasitic
  • i. Antimalarial
  • j. Vitamins, Minerals, Antioxidants, Nutritional Drugs
  • k. Analgesic, Anti-inflammatory Drugs
  • l. Pesticides
  • CONCLUSIONS
  • ABBREVIATIONS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Optical Sensor Arrays for Pharmaceutical and Biomedical Analyses
  • Pavel Anzenbacher, Jr*, 1 and Mehmet Gokhan Caglayan2
  • INTRODUCTION
  • Chemometric Analysis of Optical Array Sensors
  • Principal Component Analysis
  • Linear Discriminant Analysis
  • Support Vector Machines
  • Hierarchical Cluster Analysis
  • Neural Networks
  • Optical Array Sensing in Pharmaceutical and Biomedical Analyses
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • Applications of Ionic Liquids in Chemical Science
  • Imran Ali1,*, Zeid A. Alothman2, Abdulrahman Alwarthan2 and Hassan Y. Aboul-Enein3,*
  • INTRODUCTION
  • Significance of the Ionic Liquids
  • Applications of the Ionic Liquids
  • Extraction
  • Separation
  • Liquid Chromatography
  • Capillary Electrophoresis
  • Gas Chromatography
  • Electrochemistry
  • Spectroscopy
  • TOXICITY
  • FUTURE PROSPECTIVE
  • CONCLUSION
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES
  • New Trends in Enantioanalysis of Pharmaceutical Compounds using Electrochemical Sensors
  • Raluca-Ioana Stefan-van Staden*
  • ENANTIOANALYSIS - A NEED FOR PHARMACEUTICAL INDUSTRY
  • TYPES OF ENANTIOSELECTIVE, ELECTROCHEMICAL SENSORS USED IN ENANTIOANALYSIS
  • DESIGN OF ENANTIOSELECTIVE SENSORS
  • Chiral Selectors Used in the Design of the Enantioselective, Potentiometric Membrane Electrodes
  • Design of Carbon Paste Based Enantioselective Electrodes
  • Design of Diamond Paste Based Enantioselective Electrodes
  • Design of PVC Based Enantioselective, Potentiometric Membrane Electrodes
  • Design of Molecularly Imprinted Polymers Based Enantioselective Sensors
  • PHARMACEUTICAL ENANTIOANALYSIS USING POTENTIOMETRIC SENSORS
  • Enantioselective, Potentiometric Membrane Electrodes Based on Polyaniline Films
  • Enantioselective, Potentiometric Membrane Electrodes Based on Cyclodextrins
  • Enantioselective, Potentiometric Membrane Electrodes Based on Maltodextrins
  • Enantioselective, Potentiometric Membrane Electrodes Based on Antibiotics
  • Enantioselective, Potentiometric Membrane Electrode Based on Crown Ethers
  • Enantioselective, Potentiometric Membrane Electrode Based on Fullerenes
  • PHARMACEUTICAL ENANTIOANALYSIS USING AMPEROMETRIC SENSORS
  • PHARMACEUTICAL ENANTIOANALYSIS USING STOCHASTIC SENSORS
  • CONCLUSIONS
  • CONSENT FOR PUBLICATION
  • CONFLICT OF INTEREST
  • ACKNOWLEDGEMENTS
  • REFERENCES

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