Handbook of Mitochondrial Dysfunction

 
 
CRC Press
  • erschienen am 15. Mai 2019
  • |
  • 502 Seiten
 
E-Book | ePUB ohne DRM | Systemvoraussetzungen
978-0-429-81176-0 (ISBN)
 

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.

Key Features

    • Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.

    • Includes summary of both causes and effects of these diseases.

    • Discusses current and potential future therapies for mitochondrial dysfunction diseases

    • Explores a wide variety of diseases caused by dysfunctional mitochondria.

    • Englisch
    • London
    • |
    • Großbritannien
    Taylor & Francis Ltd
    • Für höhere Schule und Studium
    51 schwarz-weiße und 33 farbige Abbildungen, 19 schwarz-weiße Tabellen
    • 71767,69 MB
    978-0-429-81176-0 (9780429811760)
    Shamim I. Ahmad earned his


    Master's degree in Botany from


    Patna University, Bihar, India, and


    his PhD in Molecular Genetics


    from Leicester University, England.


    He then joined Nottingham


    Polytechnic as a grade 1 lecturer and subsequently was


    promoted to the post of Senior Lecturer. Ahmad now


    spends much of his time producing/writing medical


    books. For more than three decades he researched different


    areas of molecular biology/genetics including thymineless


    death in bacteria, genetic control of nucleotide


    catabolism, development of anti-AIDs drug, control of


    microbial infection of burns, phages of thermophilic bacteria,


    and microbial flora of Chernobyl after the nuclear


    power station accident. But his main interest is DNA


    damage and repair specifically by near-ultraviolet light


    mostly through the photolysis of biological compounds,


    production of reactive oxygen species, and their implications


    on human health including skin cancer. He also


    investigates near-ultraviolet photolysis of non-biological


    compounds such as 8-metoxypsoralen, mitomycin C, and


    their importance in psoriasis treatment and in Fanconi


    anemia. He has collaborated with the University of


    Osaka, Japan, and he and his colleagues were able to


    show that a number of naturally occurring enzymes were


    able to scavenge the reactive oxygen species.


    In 2003 he received a prestigious Asian Jewel Award


    in Britain for Excellence in Education. His long time ambition


    to produce medical books started in 2007 and since


    then he has published Molecular mechanisms of Fanconi


    Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;


    Molecular Mechanisms of Cockayne Syndrome;


    Molecular Mechanisms of Ataxia Telangiectasia; Diseases


    of DNA repair; Neurodegenerative diseases; Diabetes: an


    Old Disease a New Insight, Obesity: a Practical Guide,


    Thyroid: Basic Science and Clinical Practice, and Ultraviolet


    light in Human Health, diseases and environment; also


    as a co-author the book on Diabetes: A comprehensive


    Treatise for patients and Caregivers. His most recent books


    are Reactive Oxygen Species in Biology and Human Health


    and Aging: Exploring a Complex Phenomenon.
    Contents


    Preface ........................................................................................................................................................................... xi


    Acknowledgment......................................................................................................................................................... xiii


    About the Editor .......................................................................................................................................................... xv


    Contributors ............................................................................................................................................................... xvii


    SECTION I Introduction: Structure and Function of Mitochondria


    Chapter 1 Mitochondrial Structure and Function ....................................................................................................... 3


    Marcos Roberto de Oliveira


    Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria ................................................................ 9


    Puja Agarwal, Mehali Mitra, and Sujit Roy


    Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair ........................................................................23


    Kalyan Mahapatra, Sayanti De, and Sujit Roy


    SECTION II Mitochondrial Dysfunction and Diseases


    Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases ..................................................39


    Katarzyna Tonska


    Chapter 5 Kearns-Sayre Syndrome .............................................................................................................................55


    Josef Finsterer


    Chapter 6 Mitochondrial Dysfunction and Barth Syndrome......................................................................................61


    Arianna F. Anzmann, Steven M. Claypool, and Hilary Vernon


    Chapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer's Disease ..............................................79


    Isaac G. Onyango


    Chapter 8 Mitochondrial Dysfunction in Multiple Sclerosis.......................................................................................87


    Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, and Michal Bijak


    Chapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease.............................................................................93


    Maria V. Irazabal and Alfonso Eirin


    Chapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to Clinical


    Therapeutics.............................................................................................................................................103


    Thalita Basso Scandolara, Leticia Madureira Pacholak, Thayse Fachin Cormanique, Rodrigo Kern,


    and Carolina Panis


    Chapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis ....................................................115


    Silvio Zaina and Gertrud Lund


    Chapter 12 Mitochondrial Dysfunction and Heart Diseases ......................................................................................127


    Dao-Fu Dai


    Chapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer .......143


    Jan Jezek


    Chapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma .......................................................................151


    Naveen K. Bhatraju and Anurag Agrawal


    Chapter 15 Mitochondrial Dysfunction and Hearing Loss.........................................................................................163


    Maria de la Luz Arenas Sordo


    Chapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases ............................171


    Jahaun Azadmanesh and Gloria E. O. Borgstahl


    Chapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction


    and Human Brain Pathologies .................................................................................................................191


    Vismaya, Yogachar Chithra, and Muchukunte Mukunda Srinivas Bharath


    Chapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis ..............205


    Pu Duann, Elias A. Lianos, and Pei-Hui Lin


    Chapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury ....................................217


    David Blitzer, Borami Shin, Alvise Guariento, Pedro J. del Nido, and James D. McCully


    Chapter 20 Mitochondrial Dysfunction in Diabetes ...................................................................................................231


    Eric L. Johnson


    Chapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood............................................................243


    Martin Magner


    Chapter 22 Mitochondrial Dysfunction and Epilepsies ..............................................................................................265


    Bindu Parayil Sankaran and Arun B. Taly


    Chapter 23 Mitochondrial Dysfunction and Allergic Disease.....................................................................................277


    Kritika Khanna and Anurag Agrawal


    SECTION III Factors Affecting Mitochondrial Function


    Chapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria ....................................................................293


    Marcos Roberto de Oliveira


    Chapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle .........................................309


    Teet Seene


    Chapter 26 The Effects of Resveratrol on the Brain Mitochondria.............................................................................319


    Marcos Roberto de Oliveira


    Chapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise .................335


    Sergej M. Ostojic


    Chapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations .....................................................341


    Carlos Ortez and Andres Nascimento


    Chapter 29 Mitochondrial Stress and Cellular Senescence..........................................................................................361


    Irene L. Tan and Michael C. Velarde


    Chapter 30 Role of Mitochondrial Dysfunction in Human Obesity ...........................................................................379


    David Albuquerque, Sara Silva, Daniel Alvarez-Vaca, Celia Aveleira, and Clevio Nobrega


    Chapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells...................................389


    Feres Jose Mocayar Maron, Emiliano Diez, Russel J. Reiter, and Walter Manucha


    Chapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy


    and Avenues for Therapy..........................................................................................................................399


    Jennifer Jossart, Taylor N. Dennis, and J. Jefferson P. Perry


    Chapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome................409


    Qiaozhu Su and Hao Wang


    SECTION IV Immunity and Toxicity


    Chapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics ..............................................................425


    Mohsin Khan, Hasan Imam, and Saiful Anam Mir


    Chapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments.........................443


    Elise Jacquin, Eric Hervouet, and Michael Boyer-Guittaut


    Chapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption........................................................461


    Alan J. Hargreaves


    Chapter 37 Mitochondrial Dysfunction in Friedreich Ataxia .....................................................................................471


    Rosella Abeti, Annalisa Baccaro, and Paola Giunti


    Index............................................................................................................................................................................477
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