Part I: Injury at Capillary Endothelial Cell Level: 1. Ultrastructural Aspects of Capillary Barrier Function After Injury; 2. Hypoxia-Induced Modulation of Endothelial Cell Function; Part II: Increased Capillary Permeability Conditions: 3. Microcirculatory Exchange of Fluid and Protein and Development of the Third Space; 4. The Third Space Phenomenon and the Theory of Third Space; 5. Clinical Manifestations of Increases in Microvascular Permeability; Part III: Reperfusion Injuries: 6. Microcirculatory Dysfunction in Ischemia: Reperfusion Injury; 7. Cardiac Reperfusion Injury; 8. Reperfusion Injury in Extremity Ischemia; 9. Shock Syndromes as Reperfusion Injuries: Pathophysiology, Hemodynamic and Oxygen Transport Patterns, Outcome Prediction and Therapy; Part IV: Problems of Reperfusion Injury In Transplantation: 10. Reperfusion Injury After Heart Transplantation; 11. Reperfusion Injury in Lung Transplantation; 12. Problems of Reperfusion Injury in Organ Transplants: The Kidney; 13. Reperfusion Injury and Liver Transplantation; 14. Ischemia Reperfusion Injury in Pancreas Organ Transplantation; Part V: Multiple Organ Failure: 15. Clinical Aspects of Multiple Organ Failure; 16. A Unified Theory of Multiple Organ Failure: Generalized Inflammation; 17. Mechanism of Multiple System Organ Failure; Part VI: New Horizons In The Treatment of Shock and Reperfusion Injuries: 18. Protection and Reversal in Ischemia-Reperfusion Tissue Injury; 19. Intestinal Ischemia-Reperfusion Injury: Pathophysiology, Prevention and Treatment 20. Immunological Approaches in the Treatment of Sepsis and Shock: A Review; 21. A Biophysical Approach: "Sealing" of Capillary Leak by Intravenous Biodegradable Macromolecules