List of Contributors, v
Preface, ix
Acknowledgements, x
Section 1 Approach to Abnormal Blood Tests
1 Diagnostic Approach to Anaemia in Critical Care, 3
Stephen F. Hawkins and Quentin A. Hill
2 Leukopenia, 9
Stephen F. Hawkins, Jecko Thachil and Quentin A. Hill
3 Thrombocytopenia in the Intensive Care Unit, 12
Jecko Thachil
4 High Blood Counts, 16
Quentin A. Hill
5 The Abnormal Clotting Profile, 26
Jecko Thachil
6 Understanding the Blood Film, 31
Stephen F. Hawkins and Quentin A. Hill
Section 2 Approach to Coagulation Problems
7 Venous Thromboembolism in Intensive Care, 39
Sarah A. Bennett and Roopen Arya
8 Reversal and Monitoring of Anticoagulants, 45
Joost J. van Veen
9 Disseminated Intravascular Coagulation, 52
Jecko Thachil
10 Heparin-Induced Thrombocytopenia, 58
Jerrold H. Levy and Anne M. Winkler
11 Thrombotic Microangiopathies, 62
Mari Thomas and Marie Scully
12 Critical Care of Patients with a Congenital Bleeding Disorder, 69
Vanessa Martlew
Section 3 Approach to Transfusion Problems
13 Blood Components and Their Contents, 77
Shubha Allard
14 Transfusion Reactions, 86
Therese A. Callaghan
15 The Management of Non-traumatic Massive Haemorrhage, 93
Nicola S. Curry and Simon J. Stanworth
16 Plasma Exchange, 100
Khaled El-Ghariani
Section 4 Approach to Red Cell Problems
17 Appropriate Haemoglobin in Intensive Care, 107
Jonathan Wallis and Stephen Wright
18 Sickle Cell Disease and Thalassaemia in the Critical Care Setting, 112
Andrew Retter and Jo Howard
19 Management of Patients Who Refuse Blood Transfusion, 118
Derek R. Norfolk and Fran Hartley
Section 5 Approach to White Cell Problems
20 Infectious Complications in the Immunosuppressed Patient, 125
Tim Collyns and Elankumaran Paramasivam
21 Haematopoietic Stem Cell Transplantation (HSCT), 135
John Snowden and Stephen Webber
22 Multiple Myeloma and Hyperviscosity Syndrome, 144
Amin Rahemtulla and Joydeep Chakrabartty,
23 Palliative Care for the Patient with Haematological Malignancy in Intensive Care, 148
Suzanne Kite
Section 6 Admission to Intensive Care
24 Haematological Malignancy Outside Intensive Care: Current Practice and Outcomes, 159
Charlotte Kallmeyer
25 Early Care of the Unstable Patient: Preventing Admission to the Intensive Care Unit, 165
Andrew Breen
26 Decisions to Intensify Treatment: Who Will Benefit from Intensive Care?, 171
Quentin A. Hill and Peter A. Hampshire
Section 7 Point-of-Care Testing
27 The Relevance of Thromboelastography in Intensive Care Patients, 179
Jon Bailey and Nicola S. Curry
Section 8 Haematology Drugs in Critical Care
28 Recombinant Activated Coagulation Factor VII (rFVIIa) in Critical Care, 187
Leon Cloherty and Richard Wenstone
29 The Use of Haemostatic Drugs in Post-operative Bleeding, 192
Catharina Hartman and Nigel Webster
30 Delivering Chemotherapy on Intensive Care, 196
Arvind Arumainathan and Daniel Collins
Section 9 Haematology in Paediatric and Neonatal Intensive Care
31 Neonatal Anaemia, 207
Michael Richards
32 Haemolysis, 213
Michael Richards
33 Approach to Thrombocytopenia, 219
Amrana Qureshi
34 Blood Component Therapy in Children and Neonates, 224
Anne Kelly, Simon J. Stanworth and Helen V. New
Section 10 Haematological Emergencies
35 Haematological Emergencies, 235
Quentin A. Hill and Amin Rahemtulla
Appendix A: Adult, Paediatric and Neonatal Haematology Reference Intervals, 243
Quentin A. Hill
Index, 249
