The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise "stimuli-responsive" materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.
Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
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Fundamentals of Stimuli-Responsive Drug and Gene Delivery Systems; Materials and Chemistry of Stimuli-Responsive Drug Delivery Systems; pH-responsive drug delivery systems; Thermo-Responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract; Redox-Responsive Drug Delivery Systems; Magnetically-Responsive DDS; Light-responsive Drug Delivery Systems; Integrated Polymer Composites for Electro-Responsive Drug Delivery; Enzyme-responsive drug delivery systems; Swelling-Controlled Drug Delivery Systems; Biologically-Inspired Stimuli-Responsive DDS; Stimuli-Responsive Materials in Theranostics; Stimuli-responsive material inspired drug delivery systems and devices; Regulatory and Commercialization Challenges with Stimuli-Responsive Nanomedicines