Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Maße
Höhe: 229 mm
Breite: 152 mm
Gewicht
ISBN-13
978-0-8247-9549-8 (9780824795498)
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Schweitzer Klassifikation
Herausgeber*in
University of Basel, Switzerland
University of Basel, Switzerland
Phosphate-metal ion interactions of nucleotides and polynucleotides; sugar-metal ion interactions; dichotomy of metal ion binding to N1 and N7 of purines; general conclusions from sold state studies of nucleotide-metal ion complexes; solution studies of nucleotide-metal ion complexes - isomeric equilibria; stacking interactions involving nucleotides and metal ion complexes; the effect of metal ions on hydrolytic reactions of nucleotides and their phosphoesters; metal complexes of sulfur-containing purine derivatives; mechanistic insight from kinetic studies on the interaction of model palladium (II) complexes with nucleic acid components; platinum (II)-nucleobase interactions - a kinetic approach; NMR studies of oligonucleotide-metal ion interactions; metal ion interactions with DNA - considerations on structure, stability and effects from metal ion binding; electron transfer reactions through the double helix; the role of metal ions in ribozymes; ternary metal-nucleic acid base-protein complexes; metal responsive gene regulation and the zinc metalloregulatory model; the role of iron-sulfur proteins in gene regulation; current status of structure-activity relationship of platinum anticancer drugs - activation of the trans-geometry; cisplatin and derived anticancer drugs - mechanism and current status of DNA binding; proteins that bind to and mediate the biological activity of platinum anticancer drug-DNA adducts; interactions of metallopharmaceuticals with DNA.
