Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process.
With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.
- Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population
- Addresses the effect of time and age on human stem cells
- Includes chapters from contributors exploring the biology of stem cell aging around the globe
Surajit Pathak is an Associate Professor of Allied Health Sciences, Chettinad Hospital, Chennai, India. His post-doctoral research is focused on the identification of biomarkers involved in the pathogenesis of cancer in order to assess their relevance to improve the clinical management of cancer patients. Dr. Pathak has expertise in studying the role of microRNAs in diagnosis, prognosis, prediction and treatment of colorectal cancer and inflammatory bowel disease and therapeutics aspects of CD133+ stem cell. He has been involved in a range of activities, such as teaching general laboratory methods and supervision of medical and biology students and guiding in experimental planning, analysis and presentation of results. In addition to experience with most current molecular biological techniques and studies on patient materials, his accomplished background includes fluency and solid communication capabilities as being an individual in a cross-cultural environment and multi-disciplinary areas. Antara Banerjee is an Assistant Professor of Allied Health Sciences, Chettinad Hospital, Chennai, India. Her research interests are: Stem Cell Biology / Regenerative Medicine, Toxicology, Molecular Biology, Gastroenterology, and Alternative Medicine. She has published 30+ journal articles, contributed 8 book chapters and has been an invited speaker/lecturer at various international conferences and workshops.
1. Aging and stability 2. Therapeutic approaches for the treatment of aging-induced stem cell dysfunction 3. Cellular aging and senescence 4. Theories of stem cell aging 5. Aging and neural stem cells 6. Stem cells and neurodegenerative disorders 7. Muscle cells aging and stem cells 8. Progress in human embryonic stem cell research and aging 9. Signaling pathways influencing stem cells self-renewal and differentiation 10. Hematopoietic stem cells and aging: Mechanisms and consequences 11. Potential regeneration of cardiomyocytes
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