Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Homogeneous and Heterogeneous Approaches
 
 
Springer (Verlag)
  • 2. Auflage
  • |
  • erschienen am 19. April 2016
 
  • Buch
  • |
  • Hardcover
  • |
  • XXII, 483 Seiten
978-3-319-27596-3 (ISBN)
 
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)
Book
2nd ed. 2016
  • Englisch
  • Cham
  • |
  • Schweiz
Springer International Publishing
  • Für Beruf und Forschung
  • |
  • Research
  • Überarbeitete Ausgabe
  • 156 s/w Abbildungen, 1 farbige Tabelle, 1 farbige Abbildung
  • |
  • 156 schwarz-weiße und 1 farbige Abbildungen, Bibliographie
  • Höhe: 241 mm
  • |
  • Breite: 156 mm
  • |
  • Dicke: 35 mm
  • 907 gr
978-3-319-27596-3 (9783319275963)
10.1007/978-3-319-27598-7
weitere Ausgaben werden ermittelt
Part I: Basic Concepts.- The Geometry of Nature.- Diffusion and Kinetics.- Nonlinear Dynamics.- Part II: Modeling in Biopharmaceutics.- Drug Release.- Drug Dissolution.- Oral Drug Absorption.- Part III: Modeling in Pharmacokinetics.- Empirical Models.- Deterministic Compartmental Models.- Fractional Pharmacokinetics.- Modeling and Simulation in Bioequivalence.- Stochastic Compartmental Models.- Part IV: Modeling in Pharmacodynamics.- Classical Pharmacodynamics.- Nonclassical Pharmacodynamics.- Appendices.
The state of the art in Biopharmaceutics, Pharmacokinetics, and
Pharmacodynamics Modeling is presented in this new second edition book.
It shows how advanced physical and mathematical methods can expand
classical models in order to cover heterogeneous drug-biological
processes and therapeutic effects in the body.

The book is divided
into four parts; the first deals with the fundamental principles of
fractals, diffusion and nonlinear dynamics; the second with drug
dissolution, release, and absorption; the third with epirical,
compartmental, and stochastic pharmacokinetic models, with two new
chapters, one on fractional pharmacokinetics and one on bioequivalence;
and the fourth mainly with classical and nonclassical aspects of
pharmacodynamics. The classical models that have relevance and
application to these sciences are also considered throughout. This
second edition has new information on reaction limited models of
dissolution, non binary biopharmaceutic classification system, time
varying models, and interface models. Many examples are used to
illustrate the intrinsic complexity of drug administration related
phenomena in the human, justifying the use of advanced modeling methods.

This
book will appeal to graduate students and researchers in pharmacology,
pharmaceutical sciences, bioengineering, and physiology.

Reviews of the first edition:

"This
book presents a novel modelling approach to biopharmaceutics,
pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art
volume will be helpful to students and researchers in pharmacology,
bioengineering, and physiology. This book is a must for pharmaceutical
researchers to keep up with recent developments in this field." (P. R.
Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)

"These
authors are the unique (or sole) contributors in this area that are
working on these questions and bring a special expertise to the field
that is now being recognized as essential to understanding biological
system and kinetic/dynamic characteristics in drug development.This
text is an essential primer for those who would envision the
incorporation of heterogeneous approaches to systems where homogeneous
approaches are not sufficient to describe the system." (Robert R. Bies,
Journal of Clinical Pharmacology, Vol. 46, 2006)

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