Pharmacokinetic Analysis

A Practical Approach
Technomic Publishing Co
  • 1. Auflage
  • |
  • erschienen am 7. Juni 1996
  • Buch
  • |
  • Hardcover
  • |
  • 568 Seiten
978-1-56676-425-4 (ISBN)
This insightful work provides a useful introduction to the very large and important field of pharmacokinetics. The authors have selected the Time Constant Approach as a unifying view within which to present important application areas. In addition to providing consistency, their approach provides the novice with an intuitive time view that is meaningful from the outset. This approach allows one to get a "feel" for the data and to relate it to other data in a direct and accessible manner.
The Time Constant Approach provides a synthesis of the noncompartmental and compartmental methods, with the advantages of both. It starts by defining a physiologically meaningful model based on the pharmacokinetic processes involved. The Time Constant Approach recognizes pharmacokinetics as a number of processes that move drugs between physiological compartments, each process occurring at its own characteristic length of time, to correlate descriptive pharmacokinetic events with time constants of pharmacokinetic processes. While analogous to the three most common testing approaches for pharmacokinetics (the noncompartmental, compartmental and statistical moment approaches) the Time Constant Approach possesses many advantages.
  • Englisch
  • Lancaster
  • |
  • USA
Technomic Publishing Co ,U.S.
  • Für Beruf und Forschung
  • |
  • This new text will interest both novices and specialists in the pharmacokinetics field (undergraduate and graduate students, pharmacokineticists, pharmacologists and other pharmaceutical researchers and scientists), as well as those from other disciplines.
  • Höhe: 229 mm
  • |
  • Breite: 152 mm
  • 930 gr
978-1-56676-425-4 (9781566764254)
Section I: Basics and Methods * IntroductionTime Constant ApproachEvaluation of Time Constants by Visual Inspection of ConcentrationTime ProfilesScaling of Time Constants Among Different Animal SpeciesSection II: Formulation Factors Influence of Administration Route on PharmacokineticsBioavailabilityInfluence of Formulation on PharmacokineticsBioequivalenceInfluence of Dosage on PharmacokineticsDose ProportionalityPharmacokinetics of Sustained Release and Immediate Release FormulationsSection III: Absorption, Distribution, Metabolism, and Pharmacodynamics * Absorption of Drugs in Gastrointestinal TractDrug Distribution into TissueTissue PenetrationPharmacokinetics of MetabolitesRelationship between Pharmacokinetics and PharmacodynamicsSection IV: Interactions Influences of Food on PharmacokineticsEffects of Drug Interactions on PharmacokineticsSection V: Special Population Influence of Age on PharmacokineticsDifference in Pharmacokinetics between GendersSpecial Pharmacokinetic Considerations in Renal ImpairmentSpecial Pharmacokinetic Considerations in Hepatic ImpairmentSpecial Pharmacokinetic Considerations in Other DiseasesAppendices:Derivation of Mean Residence Time from Input and Output TimesDerivation of AUC and AUMC Using Laplace TransformDerivation of AUC and AUMC in the Pharmacokinetic ModelsIndex

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