Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography - mass spectrometry, capillary electrophoresis - mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
Dr. Shen Hu
is a Professor at the University of California, Los Angeles, and currently directs the Oral Biology Graduate Program. He received his PhD in Bioanalytical Chemistry from Wuhan University and MBA from the Anderson School of Management at the University of California, Los Angeles. Dr. Hu's research interests are in cancer metabolomics, stem cell biology and single cell analysis. His laboratory is developing diagnostic tools for early cancer detection and therapeutic drugs targeting the metabolic pathways of cancer.
1. NMR-Based Metabolomics in Cancer Research2. Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics3. Chemical Isotope Labeling LC-MS for Metabolomics4. Single cell metabolomics by mass spectrometry imaging5. Fatty Acid Metabolism and Cancer6. Metabolomics of Gastric Cancer7. HIF-1a metabolic pathways in human cancer8. Regulation of glycolysis in head and neck cancer9. Metabolomics of oral/head and neck cancer10. Ion chromatography with mass spectrometry for metabolomic analysis11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy13. Metabolomics of glioma14. Microbial metabolomics: From methods to translational applications15. Advances in the study of N6-methyladenine in eukaryotes16. NMR Based Metabolomics17. Quantitative analysis of oncometabolite 2-hydroxyglutarate18. Tracer-based Cancer Metabolomic Analysis19. Mass spectrometry-based shotgun lipidomics for cancer research20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics
This book will be divided into four main areas: (1) Metabolomics technology. Most advanced technology platforms for metabolomics will be introduced, including CE-MS, CIC-MS, GC-MS, NMR and tracer-based metabolomics; (2) Data analysis tools for metabolomics; (3) Clinical application of metabolomics. These will include biomarker discovery for cancer early detection, prognosis, therapy monitoring and cancer recurrence; (4) New discovery in cancer metabolism. This topic will include some of the recent novel discovery in cancer metabolism such as HIF1alpha pathway, IDH1 mutation, oncometabolite, etc. This is to stimulate more applications of metabolomics in cancer biology (metabolism).