Cyclic Peptide Design

 
 
Humana Press Inc.
  • erschienen am 28. Mai 2019
 
  • Buch
  • |
  • Hardcover
  • |
  • X, 332 Seiten
978-1-4939-9503-5 (ISBN)
 
This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature's cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.
1st ed. 2019
  • Englisch
  • NY
  • |
  • USA
  • Für Beruf und Forschung
  • 58 s/w Abbildungen, 80 farbige Abbildungen, 82 farbige Tabellen
  • |
  • 54 schwarz-weiße und 82 farbige Abbildungen, Bibliographie
  • Höhe: 261 mm
  • |
  • Breite: 179 mm
  • |
  • Dicke: 27 mm
  • 832 gr
978-1-4939-9503-5 (9781493995035)
10.1007/978-1-4939-9504-2
weitere Ausgaben werden ermittelt

1. Design Principles for Intestinal Permeability of Cyclic Peptides

Alan M. Mathiowetz

2. Strategies to Enhance Metabolic Stabilities

Bhavesh Khatri, Venkateswara Rao Nuthakki, and Jayanta Chatterjee

3. Designing Cell-Permeable Macrocyclic Peptides

George Appiah Kubi, Patrick G. Dougherty, and Dehua Pei

4. Computational Methods for Studying Conformational Behaviors of Cyclic Peptides

Fan Jiang and Hao Geng

5. Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions

Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, and Denis Shields

6. Design of Cyclic Peptides as Protein Recognition Motifs

Ye Che

7. Design and Synthetic Strategies for Helical Peptides

Licheng Tu, Dongyuan Wang, and Zigang Li

8. Click Chemistry for Cyclic Peptides Drug Design

Adel Ahmed Rashad

9. Frontier between Cyclic Peptides and Macrocycles

Philipp Ermert, Anatol Luther, Peter Zbinden, and Daniel Obrecht

10. Building upon Nature's Framework: Overview of Key Strategies towards Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles

Maria-Jesus Blanco

11. Design of Oxytocin Analogs

Kazimierz Wisniewski

12. DNA-Encoded Macrocyclic Peptide Library

Zhengrong Zhu, Alex Shaginian, LaShadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal, Praew Thansandote, and Graham L. Simpson

13. Peptide Display Technologies

Anthony Pitt and Zeke Nims

14. Discovery of Functional Macrocyclic Peptides by Means of the RaPID System

Christos Tsiamantas, Manuel E. Otero-Ramirez, and Hiroaki Suga

15. Genetic Selections with SICLOPPS Libraries: Towards the Identification of Novel Protein-Protein Interaction Inhibitors and Chemical Tools

Francisco Castillo and Ali Tavassoli

This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature's cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field.
Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.

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