Diverse Roles of PKCa in Vascular Smooth Muscle Contraction

LAP Lambert Academic Publishing
  • erschienen am 16. Januar 2018
  • Buch
  • |
  • Softcover
  • |
  • 144 Seiten
978-3-330-07409-5 (ISBN)
This book is divided into four chapters. The first chapter represents a general review of the literature of relevant topics. Chapter two is a manuscript previously published in the American Journal of Physiology, Cell Physiology, reproduced with the kind permission of the American Physiological Society. This chapter describes the association between ß-tubulin and PKCa and reports a novel cell structure dependent on this interaction. Chapter three is a manuscript recently submitted to Acta Physiologica. This paper examines PKCa's association with one of its substrates, calponin (CaP), and the impact of changes in CaP expression levels on a-actin cytoskeletal structure. Here we show that calponin may have a novel role in contraction, contributing to actin structural stability through cross-linking of actin filaments. Chapter four contains a brief discussion of the results and implications of both manuscripts, as well as recommendations for future research. In addition to a discussion of the factors contributing to the unique smooth muscle (SM) contraction, a review of certain techniques will follow. These methods were pioneered for use in the study of SM within our laboratory.
  • Englisch
  • Höhe: 220 mm
  • |
  • Breite: 150 mm
  • |
  • Dicke: 9 mm
  • 231 gr
978-3-330-07409-5 (9783330074095)
3330074094 (3330074094)
Ava DykesAssociate Service Fellow at NIOSH MorgantownNIOSH Marshall University Joan C. Edwards School of MedicineMorgantown, West Virginia.

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