
Chalcones
From Drug Discovery to Pharmaceutical Applications
Academic Press
Erscheint ca. am 1. April 2026
Buch
Softcover
500 Seiten
978-0-443-43812-7 (ISBN)
Beschreibung
Chalcones: From Drug Discovery to Pharmaceutical Applications offers an exploration of chalcones, organic compounds renowned for their versatile chemistry and significance in drug research. This detailed reference discusses the natural sources of chalcones, their extraction and synthesis techniques, and their importance in developing innovative pharmaceuticals. Both newcomers and seasoned professionals will find foundational insights, methodologies for structural characterization, and the growing role these compounds play in advancing therapeutic solutions for a wide range of medical conditions. This resource stands out for its critical guidance on drug development strategies and its broad overview of chalcones' potential to address complex health challenges.
The book is divided into three comprehensive sections: "Foundations of Chalcones Research," which examines chalcone origins and laboratory methods; "Pharmacology of Chalcones," detailing their pharmacokinetics, safety profiles, and unique medicinal properties, including antiviral, antibacterial, anticancer, and neuroprotective effects; and "Prospects," focusing on drug formulation, chalcone-based clinical trials, and future pharmaceutical applications.
The book is divided into three comprehensive sections: "Foundations of Chalcones Research," which examines chalcone origins and laboratory methods; "Pharmacology of Chalcones," detailing their pharmacokinetics, safety profiles, and unique medicinal properties, including antiviral, antibacterial, anticancer, and neuroprotective effects; and "Prospects," focusing on drug formulation, chalcone-based clinical trials, and future pharmaceutical applications.
Weitere Details
Sprache
Englisch
Verlagsort
San Diego
USA
Verlagsgruppe
Elsevier Science Publishing Co Inc
Zielgruppe
Für Beruf und Forschung
Produkt-Hinweis
Broschur/Paperback
Klebebindung
Maße
Höhe: 235 mm
Breite: 191 mm
Gewicht
450 gr
ISBN-13
978-0-443-43812-7 (9780443438127)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
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Andere Ausgaben

Simone Carradori | Davide Moi | Ilaria D'Agostino
Chalcones
From Drug Discovery to Pharmaceutical Applications
E-Book
05/2026
Elsevier
185,99 €
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Personen
Dr. Carradori is a very prolific researcher with papers dealing with both synthetic and natural products characterized by promising biological activities. Regarding this topic, he has been involved in the study of HAT inhibitors, hCA IX and XII inhibitors, kinesin Eg5 inhibitors and natural compounds active in the field of oncology. Recently, he has been focusing on "drug repurposing? disclosing a patent on new roles played by antiparasitic benzimidazoles as anti-cancer agents. He also was Co-Guest Editor of several special issues, co-author of chapters for two books (one edited by Elsevier) and acts as Editorial Board member of several peer-reviewed journals. Dr. Moi Davide is a researcher involved in the design, synthesis, and characterization of small molecules endowed with promising biological activity. He is mainly involved in the study of compounds with multitarget activity in the cancer field, as well as in the study of epigenetic modulators, such as HDACs and Carbonic Anhydrase modulators. In the last years, he has been involved in the synthesis of high-value scaffolds through photo- and organo-catalysis, as well as in the development of fluorescent molecules for bio-imaging. He is also the author of several research articles and, Guest and Co-Guest editor of different special issues.
Dr. Ilaria D'Agostino is a medicinal chemist involved in the development of small molecules as putative anticancer, antifibrotic, and antiinfective agents and hybrid compounds for a multitarget approach. Currently, she is mainly involved in the design and synthesis of compounds targeting cancer stem cells for an antitumoral application along with innovative targeted theranostic agents for precision medicine. She is the author of several research articles and book chapters, and Co-Guest editor of different special issues.
Dr. Ilaria D'Agostino is a medicinal chemist involved in the development of small molecules as putative anticancer, antifibrotic, and antiinfective agents and hybrid compounds for a multitarget approach. Currently, she is mainly involved in the design and synthesis of compounds targeting cancer stem cells for an antitumoral application along with innovative targeted theranostic agents for precision medicine. She is the author of several research articles and book chapters, and Co-Guest editor of different special issues.
Herausgeber*in
Assistant professor in Medicinal Chemistry, Department of Pharmacy, "G. d'Annunzio? University of Chieti-Pescara, Italy
Department of Life and Environmental Sciences, University of Cagliari, Italy
University of Pisa, Italy
Inhalt
Part I - Foundations of Chalcones research
1. Natural sources of Chalcones
2. Extraction methods from traditional to green approaches
3. Structural and spectroscopic characterization of Chalcones
4. Synthesis, structural modifications and scale-up methods
5. Medicinal Chemistry Strategies in the Chalcone scaffold
6. Chalcones as versatile intermediates in organic chemistry
7. Chalcones in metal complexes
Part II - Pharmacology of Chalcones
8. PK properties and bioavailability of Chalcones
9. Chalcone Toxicity
10. Natural Chalcones in Traditional Medicine
11. Chalcones as Antiviral Agents
12. Chalcones as Antibacterial and Antitubercular Agents
13. Anticancer Potential of Chalcones
14. Chalcones as Neuroprotective and Anti-Alzheimer's Disease Agents
15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents
16. Chalcones as Antifungal Agents
17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents
18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating Agents
Part III - Prospects
19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)
20. Formulations and Drug Delivery of Chalcones
21. Chalcone-protein co-crystals in the PDB
22. Clinical Trials of Chalcone-based drug candidates
1. Natural sources of Chalcones
2. Extraction methods from traditional to green approaches
3. Structural and spectroscopic characterization of Chalcones
4. Synthesis, structural modifications and scale-up methods
5. Medicinal Chemistry Strategies in the Chalcone scaffold
6. Chalcones as versatile intermediates in organic chemistry
7. Chalcones in metal complexes
Part II - Pharmacology of Chalcones
8. PK properties and bioavailability of Chalcones
9. Chalcone Toxicity
10. Natural Chalcones in Traditional Medicine
11. Chalcones as Antiviral Agents
12. Chalcones as Antibacterial and Antitubercular Agents
13. Anticancer Potential of Chalcones
14. Chalcones as Neuroprotective and Anti-Alzheimer's Disease Agents
15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents
16. Chalcones as Antifungal Agents
17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents
18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating Agents
Part III - Prospects
19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)
20. Formulations and Drug Delivery of Chalcones
21. Chalcone-protein co-crystals in the PDB
22. Clinical Trials of Chalcone-based drug candidates