Part I: Setting the Stage. Big Basin, Big Challenges: An Introduction. Governing Natural Resources: Past, Present and Future. Study Purpose, Design and Methodology. Part II: Making the Case. Current Approaches in the MRB: Interagency Processes and Institutional Arrangements. Other Regional Examples: Great Lakes, Chesapeake Bay, and the Everglades. Comparisons and Contrasts. Part III: Telling the Story: Policy and Institutional Dimensions. Current Efficacy and Capacity. Intra-basin Governance Gaps: Upper and Lower Mississippi. Actor Preferences and Needed Modifications. Impediments to Adoption and Implementation of Needed Modifications. Part IV: Telling the Story: Interagency Collaboration. Current Efficacy and Importance. Biophysical Factors. Membership Factors. Institutional Factors. Resource Factors. Purpose Factors. Sociopolitical Factors. Key Findings & Conceptual Framework. Policy Implications. Recommendations. Scholarly Contributions and Conclusions. References. Appendices. Index.